Compact AI Model Predicts Protein Stability With Fewer Parameters
A compact energy-based neural network called LEEN predicts protein stability changes from single amino acid substitutions using roughly 2 to ...
Tag: Protein Engineering
Multitask Cambrian Model Improves Protein Melting Temperature Prediction
Researchers developed ESMTmP, a multiscale multitask learning model that predicts protein melting temperatures with reduced error and order-consistent outputs.
Repurposed Binuclear Copper Enzymes Enable Enantioselective Radical Halogenation Reactions
Engineered type III binuclear copper enzymes from Bacillus megaterium catalyze unnatural enantioselective radical halogenation and pseudohalogenation reactions.
Machine learning reshapes yeast enzyme to favor a stubborn aldehyde and survive heat
Machine learning-guided engineering of yeast alcohol dehydrogenase produced variants with more than doubled activity toward trans-2-nonenal, and one variant also ...
Designed From Scratch: Microproteins Take Aim at Brain Disease
De novo designed microproteins, built computationally to bind toxic amyloid fibrils and restore mitochondrial function, are emerging as promising candidates ...
Cryo-EM reveals how a retrotransposon and CRISPR–Cas9 team up to insert genes
Cryo-electron microscopy structures of the zebra finch R2 retrotransposon, alone and bound to Cas9, reveal how target-primed reverse transcription initiates ...
Watching Proteins Assemble in Real Time with a Benchtop Light-Scattering Protocol
A new open-access protocol uses continuous dynamic light scattering to track protein self-assembly minute by minute, with the full workflow ...
Engineered albumin fusion extends erythropoietin half-life and enables nasal delivery in mice
A human erythropoietin fused to an engineered albumin variant showed a 5.2-fold longer plasma half-life and successful intranasal delivery in ...
Generative AI moves crop breeding from natural selection to molecular design
A review by researchers at China Agricultural University outlines how generative AI architectures and a proposed DESIGN framework could shift ...
Loosening the Rim: Peripheral Flexibility Boosts a Cellulase’s Catalytic Power
Engineers boosted a GH5 endoglucanase's catalytic efficiency up to 2.73-fold by mutating solvent-exposed peripheral residues to loosen the catalytic cavity, ...
AI-guided enzyme search yields two new cellulases and an eightfold secretion boost in Bacillus subtilis
A new study links database-guided discovery of two uncharacterised GH5 endoglucanases with two rounds of mutagenesis and an approximately eightfold ...
Norrin complex structure guides potent engineered signaling surrogates
A structural study shows how Norrin, FZD4, TSPAN12 and LRP5 assemble, enabling engineered surrogate proteins with enhanced signaling potency.
Engineered human AGO2 enables targeted C-to-U RNA editing in cells
Engineered human AGO2 and a C-to-U deaminase produced average messenger RNA editing 1.9-fold higher than two Cas13 comparators in HEK293T ...
Fusion Platform Recovers Previously Unproducible Bacterial Toxins
A modular toxin–immunity fusion system enables the production, purification and functional analysis of highly toxic bacterial proteins that conventional recombinant-expression ...
Plants’ Double-Headed Defenders: How Multifunctional Enzyme Inhibitors Could Reshape Crop Protection
A new review in Plant Molecular Biology defines plant multifunctional inhibitors as a distinct class of double-headed defense proteins and ...
Tiny Photoswitchable Protein Opens a New Window on Deep-Tissue Molecular Imaging
Researchers engineered an 18.8-kilodalton photoswitchable near-infrared protein, rsmiRFPnano, that enables background-free photoacoustic imaging of inflammation signaling and intracellular antigens deep ...
Hepatitis C Vaccine Design Gains Ground as Structures Reveal How Naive Antibodies See Viral Envelope
New structural and biochemical analyses of the hepatitis C virus E2 glycoprotein show that germline-reverted broadly neutralizing antibodies recognize the ...
Four Proteins, One Machine: Scientists Decode How Bacterial R-Bodies Assemble and Snap Open
Researchers at Institute of Science Tokyo have revealed how four proteins cooperate through a regulated assembly pathway to build pH-responsive, ...
Protein Therapy Aims to Restore Brain Function in Fragile X Syndrome
A UC Riverside team funded by FRAXA will test engineered proteins designed to cross the blood-brain barrier and normalize brain ...
Deep Learning Reads Molecular Dynamics to Decode Protein Allostery
A new graph neural network framework called AlloPool distills molecular dynamics simulations into minimal, time-resolved interaction networks that reveal how ...
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