Phase Separation Is an Evolvable Trait, Argues New Evolutionary Framework
A new perspective argues that liquid–liquid phase separation should be studied as an evolvable molecular phenotype shaped by natural selection.
Tag: Protein Design
AI model designs working proteins from plain-language descriptions
A 16-billion-parameter AI model called Pinal designed proteins from natural-language descriptions that showed their intended functions in laboratory tests, including ...
AI-designed proteins could unlock a new generation of sweetness
Researchers used RFdiffusion, ProteinMPNN, and molecular dynamics to design novel protein binders against the human sweet taste receptor TAS1R2, creating ...
Scientists Design Artificial Enzymes That Cleave Protein Chains From Scratch
Researchers have computationally designed artificial cysteine proteases from scratch that cleave peptide bonds with rate enhancements of up to ten ...
AI-Designed Enzymes Slice Disease Proteins With Unprecedented Precision
Researchers have used AI-driven protein design to create entirely new zinc-dependent proteases that cleave disease-linked proteins such as TDP-43 and ...
AI protein design lessons from COVID-19 point to pandemic-ready vaccines
When SARS-CoV-2 first swept across the globe in early 2020, the pharmaceutical world faced a brutal mismatch: conventional vaccine and ...
RFdiffusion3 designs proteins and nucleic acids atom by atom with striking precision
The new generative AI system RFdiffusion3 designs proteins and nucleic acids atom by atom, producing functional enzymes and RNA molecules ...
AI Meets Molecular Dynamics to Design Smarter Cancer-Fighting T Cell Receptors
Researchers propose a closed-loop framework that unites AI-driven sequence design, molecular dynamics simulation, and experimental validation to rationally engineer high-affinity, ...
Two-Layer Gene Editing Delivers Elite Herbicide-Tolerant Crops
Researchers combined structure-guided protein design with cis-regulatory editing at the native HPPD locus to create elite herbicide-tolerance alleles in rice ...
Scientists Engineer Supercharged Herbicide-Resistant Crops by Editing Protein and Promoter Together
Researchers have combined structure-guided protein design with cis-regulatory enhancer insertion to create rice and wheat plants that tolerate herbicide doses ...
AI-Designed Protein Drug Recruits Immune Cells to Fight Gastric Cancer—With a Helping Hand from Dendritic Cells
A team at Nanjing Medical University used RFdiffusion to design a CLDN18.2-targeting T-cell engager for gastric cancer and showed that ...
Insulin Receptor Signaling Is Not One Pathway: Engineered Mimetics Reveal a Programmable Network
A new review argues that insulin receptor signaling is a programmable, context-dependent network that engineered mimetics can selectively retune across ...
Global AI protein design contest puts 12,000 computer-made cancer binders to the test in living T cells
A global competition benchmarked 12,000 AI-designed CD20 binders in primary human CAR-T cells, revealing common design failure modes and simple ...
AI-Designed Protein Binders Face Real-World Test in Landmark CAR T Cell Competition
A crowdsourced competition called Bits to Binders tested 12,000 AI-designed minibinders as CAR T cell recognition domains, revealing both the ...
Designing Relationships in Intrinsically Disordered Proteins
In the realm of protein science, a significant frontier has emerged, focusing on intrinsically disordered proteins (IDPs). Unlike their well-folded ...
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