Biliary Tract Cancer Guidelines Excel at Clarity but Leave Precision Oncology Pathways Incomplete
A systematic review of 27 guideline families using AGREE II and AGREE-REX finds that clinical practice guidelines for precision oncology ...
Tag: precision oncology
AI Maps Whole Gene Networks That Cancers Cannot Live Without
A machine learning framework called BioBombe maps the biological processes that cancers depend on for survival, revealing new vulnerabilities and ...
Deuterium swap turns one molecule into a brighter, tougher cancer fighter
Researchers at Shenzhen University show that replacing hydrogen with deuterium in a near-infrared fluorescent molecule simultaneously improves imaging brightness, therapeutic ...
Virtual Tumors Point to New Drug Combinations for Hard-to-Treat Lung Cancer Mutations
A new quantitative systems pharmacology model spanning all three classes of BRAF-mutant lung cancer predicts that MEK-ERK inhibitor combinations can ...
Antibody-Drug Conjugate Shows Striking First-Line Results in HER2-Driven Lung Cancer
A multicenter real-world study found that first-line trastuzumab deruxtecan doubled progression-free survival compared with chemotherapy in HER2-altered advanced NSCLC, while ...
Blood Test for Tumor DNA Predicts Survival After Cancer Treatment Before Surgery
A meta-analysis of 41 studies and 3,058 patients shows that detectable circulating tumor DNA after neoadjuvant therapy strongly predicts worse ...
Single-Cell Atlas Reveals DLL3 as a Drug Target in Aggressive Cervical Cancer
A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...
AI Reads Lymph Node CT Scans to Predict Nasopharyngeal Cancer Treatment Success
A machine learning model trained on CT texture features of metastatic neck lymph nodes predicted which patients with advanced nasopharyngeal ...
Personalized Navigation Boosts Hereditary Cancer Genetic Testing Among Relatives
A randomized trial at MD Anderson Cancer Center found that personalized navigation support raised BRCA genetic testing uptake among at-risk ...
Evolution-Tuned AI Ensemble Reads Brain Tumor Scans With Near-Perfect Accuracy
Researchers have built an explainable ensemble deep learning framework that fuses four transfer learning models using CMAES optimization to classify ...
AI Reads Tissue Maps to Forecast Cancer Survival, Cell by Cell
An explainable graph neural network called SpaCEy identifies the spatial tissue patterns and protein markers that predict cancer survival and ...
Single tRNA Molecule Found to Steer Prostate Cancer Between Drug Sensitivity and Resistance
Fred Hutch researchers report in Nature that a single transfer RNA, tRNA1Arg(UCU), controls whether prostate cancer cells remain androgen receptor-dependent ...
Engineered Immune Cells Edge Closer to Becoming a Real Weapon Against Breast Cancer
A new review maps the engineering strategies, from dual-target receptors to tumor microenvironment remodeling, that could finally bring CAR-T cell ...
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
Cancer’s Sphingolipid Code: How One Lipid Family Decides Cell Fate Across Tumors
A new review in Molecular Biology Reports maps how the ceramide–S1P balance and ganglioside signaling form a cancer-type-specific lipid code ...
AI Shows Promise Against Stomach Cancer, But Most Tools Are Not Ready for the Clinic
A comprehensive review finds that while artificial intelligence shows striking performance in detecting, staging, and predicting gastric cancer outcomes, most ...
Beyond target expression: a modular framework to predict who benefits from antibody–drug conjugates
A Nature Reviews Clinical Oncology Review proposes a modular biomarker framework that moves ADC patient selection beyond semi-quantitative immunohistochemistry by ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Hidden Genetic Fault Lines Reshape Gastric Cancer Treatment Maps in Landmark Chinese Cohort
A 563-patient genomic study from Peking University reveals how KMT2C/D loss-of-function alterations define a hypermutated, MSI-high subgroup of gastric cancer ...
Tumor Organoids Get a Four-Layer Upgrade in the Push for Precision Cancer Care
A new review in the Journal of Translational Medicine proposes a four-layer functional integration framework that combines gene editing, immune ...
