Integrated transcriptomic analyses indicate that myofibroblast-derived ANGPT2 may mediate cellular crosstalk with vascular smooth muscle cells via PI3K-AKT signaling in ...
Researchers have identified transcription factor RARG as a candidate tumor suppressor whose loss activates PI3K/AKT signaling via PTHLH downregulation in ...
A new study identifies midkine as a key mediator of cisplatin resistance in ovarian cancer, linking it to the PI3K/AKT ...
Researchers found that the conserved gene Djvcp coordinates neoblast proliferation and apoptosis to maintain tissue homeostasis and enable blastema formation ...
A study in mice reveals that WTAP-mediated m6A regulation of the insulin receptor is essential for proper ovarian follicle development ...
A study in Frontiers in Molecular Biosciences found that conditioned medium from Sanhuang Decoction-pretreated breast cancer cells reduced endothelial inflammation ...
A new study reports that restoring the integrin subunit ITGA5 accelerated wound closure in diabetic mice by protecting endothelial mitochondria ...
Investigators have identified an epigenetic mechanism in esophageal squamous cell carcinoma where METTL3-mediated m6A modification of the long non-coding RNA ...
Genomic analysis of 71 tumors from 20 patients shows most secondary chest lesions in head and neck squamous cell carcinoma ...
A new mouse study shows the approved cystic fibrosis drug ivacaftor reduced pulmonary fibrosis by suppressing senescence in alveolar type ...
A multi-platform pan-cancer analysis finds PTPN3 shows cancer-type-dependent differences in expression, survival associations, genomic alterations, phosphorylation and stromal correlations.
Transcriptome sequencing of ventilated rat diaphragms identifies MAPK, PI3K-Akt, and Calcium signaling as inflammation-linked pathways associated with muscle fiber atrophy ...
A new study reports that dihydroartemisinin suppresses melanoma by promoting ubiquitination and proteasomal degradation of the transcription factor SP1.
Extracellular vesicles from the medicinal fungus Antrodia cinnamomea suppressed hepatocellular carcinoma cell proliferation, migration and invasion in laboratory assays, apparently ...
A mouse and cell-culture study finds that the RET protein in astrocytes helps protect nearby neurons from hemin-induced apoptosis after ...
A new multi-omics study reports that myricetin from Myrica rubra binds HSP90AA1, suppresses PI3K–Akt signaling and inhibits bladder cancer growth ...
A new study in Cell Division reports that the eight-herb traditional Chinese medicine formula QSF suppresses triple-negative breast cancer growth ...
A preclinical study reports that the Tibetan formula Zang-Si-Wei and its core component ellagic acid reduced inflammation and lung damage ...
A new mouse and cell study finds that diosbulbin B, a hepatotoxic constituent of a traditional Chinese medicinal plant, intensified ...
New preclinical research shows the STAM protein suppresses clear cell renal cell carcinoma by inactivating EGFR and degrading AKT, inducing ...
