Glutarylation of XRCC4 Enhances Breast Cancer Response to PARP Inhibitors
A new study in Cellular Oncology reveals that glutarylation of the XRCC4 protein promotes its degradation, thereby enhancing the sensitivity ...
Tag: PARP inhibitors
Dutch Study Reveals Real-World Olaparib Outcomes and Genomic Testing Gaps
A nationwide Dutch registry study shows real-world olaparib therapy achieved a 13.4-month median overall survival in BRCA-mutated prostate cancer, with ...
Efflux Transporters Linked to Specific PARP Inhibitor Resistance in Ovarian Cancer
Mechanistic research links distinct efflux transporters to specific PARP inhibitor resistance in ovarian cancer, though researchers caution that clinical application ...
Review Evaluates SLC7A11 Ferroptosis Pathways in BRCA1-Mutant Breast Cancer
A review evaluates the SLC7A11-ferroptosis axis in BRCA1-mutant breast cancer, highlighting preclinical therapeutic potential alongside critical gaps in resistance mechanisms.
![SPECT/CT tracer [123I]I-PARPi mirrors PARP immunohistochemistry across cancers](https://bioengineer.org/wp-content/uploads/2026/11/stackrss-featured-1232-350x250.jpg)
SPECT/CT tracer [123I]I-PARPi mirrors PARP immunohistochemistry across cancers
A prospective imaging study of eleven patients with five different cancers found that I-PARPi SPECT/CT uptake corresponded with PARP immunohistochemistry ...
One in five men with breast cancer carries inherited cancer gene variants
A Brazilian multicenter study of 106 men with breast cancer found pathogenic germline variants in 22% of those tested, led ...
Replication Fork Instability at Specific Loci Drives PARP Inhibitor Cytotoxicity in Cells
A cell study reveals that loss of the cohesin acetyltransferase ESCO2 promotes G-quadruplex accumulation at pericentromeric regions, driving replication fork ...
TERRA R-loops turn chromosome ends into cancer’s weak spot
A new review explains how TERRA-driven R-loops at telomeres can either protect chromosome ends or fuel replication stress, genomic instability ...
CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...
Morocco builds local HRD testing for ovarian cancer, cutting reliance on foreign labs
A Moroccan cohort study of 215 advanced ovarian cancer patients found local HRD testing feasible, with 55.1 percent of evaluable ...
BRD4 emerges as key regulator of STING expression in cancer cells
BET inhibition suppresses STING expression at its promoter and enhancer regions, weakening the immune response triggered by PARP inhibitors.
Topoisomerase I Inhibitors Pair With PARP Drugs Against Resistant Ovarian Cancer
A screen of over 1400 FDA-approved compounds identified topoisomerase I inhibitors as the most effective partners for PARP inhibitors in ...
ROS-responsive nanoparticle pairs PARP inhibitor with DOT1L blocker to fire up antitumor immunity in ovarian cancer models
A ROS-responsive nanoparticle co-delivering a PARP inhibitor prodrug and a DOT1L inhibitor amplified DNA damage, activated cGAS-STING signaling and improved ...
RNA Chaperone ALYREF Hijacks Poly-ADP-Ribose at DNA Breaks and Slows Repair in Tumor Cells
Researchers report that the RNA-processing protein ALYREF binds poly-ADP-ribose at DNA double-strand breaks, delaying repair when overexpressed and marking a ...
Replication stress marker points to ovarian cancers that may yield to ALC1 targeting
New research shows that removing the chromatin remodeler ALC1 sensitizes a broad range of ovarian cancer models to PARP inhibitors ...
Symbolic AI digital twins predict breast cancer treatment response in trial simulation
UCL and Cambridge researchers developed a symbolic AI model that built digital twins of 31 breast cancer patients and correctly ...
PARP1 Disassembles Nucleosomes to Open DNA for Repair
St. Jude researchers show the DNA repair enzyme PARP1 evicts two histones near damage sites, forming hexasomes that recruit repair ...
Blood Test Tracks Prostate Cancer’s Evolving Genome in Real Time
A comprehensive review shows circulating tumour DNA offers powerful prognostic insight across all major mCRPC treatments, but its predictive use ...
AI-Designed PET Probe Reaches First Human Test for Imaging PARP-1 in Cancer
An AI-assisted design pipeline produced the gallium-68 PET tracer Ga-DOTA-FZPF, which targets PARP-1 and has now completed a first-in-human evaluation ...
Hidden Prostate Cancer Patterns That Predict Deadly Disease Are Being Missed in Biopsies
A new Nature Reviews Urology review warns that intraductal and invasive cribriform prostate cancers are aggressive, genomically unstable and frequently ...
