When a Fever Attacks the Brain and Heart: A Rare Childhood Syndrome Challenges Doctors
A case report from Tehran describes a four-year-old girl with acute necrotizing encephalopathy of childhood complicated by fulminant myocarditis, highlighting ...
Tag: Neuroinflammation
Bipolar Disorder Reimagined: A Body-Wide Feedback Loop May Drive the Mood Cycle
A new integrative review proposes that bipolar disorder arises from a destabilized feedback network linking stress hormones, mitochondrial energy failure, ...
Spatial Niches May Explain Why Brain Implants Lose Their Signal Over Time
A new analytical framework proposes that spatial niches — recurring local cellular and molecular neighborhoods around implanted microelectrodes — could ...
BTK Inhibitor Ibrutinib Speeds Remyelination via Reprogrammed Microglial Vesicles
New research shows the BTK inhibitor ibrutinib accelerates remyelination by reprogramming microglial extracellular vesicles to carry the repair-promoting microRNA miR-223.
Synapses Under Siege: How Plant Compounds May Rebuild the Brain’s Failing Connections in Alzheimer’s Disease
A new review reveals that synaptic failure—not plaque burden—is the strongest driver of Alzheimer's cognitive decline, and plant-derived phytochemicals may ...
Rethinking Remyelination: Why Brain Stimulation Plus Drugs May Crack Multiple Sclerosis Repair
A new perspective argues that pairing non-invasive brain stimulation with pro-remyelinating drugs could target both oligodendrocyte differentiation and the hostile ...
Prior Flu Infection Reshapes Brain Inflammation and Behavior in Alzheimer’s Mice
A new mouse study shows that a prior H1N1pdm influenza infection reshapes social, affective, and memory behavior and intensifies neuroinflammation ...
Stroke Reshapes Gut Microbes and Brain Chemistry in Rats, Multi-Omics Study Finds
A multi-omics study in rats reveals that permanent middle cerebral artery occlusion remodels cecal microbiota and drives a lipid-centered inflammatory ...
Gut Gene RHBDF2 Emerges as Molecular Bridge Between Colitis and Brain Barrier Damage
A multi-cohort transcriptomic, genetic, and experimental study identifies the RHBDF2–ADAM17–TNFα axis as a molecular bridge linking ulcerative colitis to blood–brain ...
Hidden Chemical Tags on DNA Reveal Immune Chaos in Fragile X-Linked Brain Disease
The first genome-wide methylation map of the FXTAS brain reveals epigenetic changes in immune, oxidative stress, and myelination genes that ...
Persistent Headache After Brain Injury May Signal Hidden Brain Dysfunction, Researchers Propose
Researchers propose that persistent post-traumatic headache may serve as a clinical signal of ongoing brain dysfunction after traumatic brain injury, ...
Gut microbes may hold the key to Alzheimer’s and Parkinson’s disease
For decades, scientists have treated Alzheimer's and Parkinson's disease as problems of the brain alone. A new review published in ...
Alzheimer’s Precision Medicine Must Fuse Cure and Care, Researchers Argue
A new Perspective argues that Alzheimer's precision medicine should treat cure and care as linked outputs of one continuously learning ...
Gut Microbes Linked to Brain Abnormalities in Childhood Vascular Disease
A new commentary in Pediatric Research highlights experimental evidence that gut microbiota from children with IgA vasculitis and neurological involvement ...
REV-ERB clock proteins emerge as Alzheimer’s disease drug targets
Deep inside the brain's immune cells, a pair of molecular clock proteins may hold the key to a radically different ...
How a Ubiquitin-Editing Enzyme in Microglia May Drive Alzheimer’s Inflammation
A new study identifies CYLD as a deubiquitinase that stabilizes microglial IKKβ, driving NF-κB–NLRP3 signaling, neuronal pyroptosis, and cognitive decline ...
Brain organoids without immune cells may miss the real story of neurodegeneration
A PLOS Biology Perspective argues that immune and vascular cells, especially microglia, must be core components of neural organoids used ...
Trehalose, the Gut Microbiome, and a New Lead in Multiple Sclerosis Research
A new review suggests that the natural sugar trehalose may influence multiple sclerosis by inducing autophagy, reducing inflammation, and reshaping ...
Brain Chemistry Meets Immune Fire: How Neurotransmitters Steer the NLRP3 Inflammasome
A new narrative review maps the complex, context-dependent crosstalk between neurotransmitter systems and the NLRP3 inflammasome, revealing bidirectional regulation with ...
Intranasal Herpes Virus Remodels Brain Immune Cells in a Region-Specific Pattern
A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...
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