Tag: Neuroinflammation

OHSU researchers have received a $5.8 million NIH grant to investigate whether lasting gut immune damage drives the neuroinflammation behind ...

A new mouse study shows that early chronic cerebral hypoperfusion spatially biases tau pathology and drives neuroinflammation at the onset ...

A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...

New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse ...

A new review charts how stem cell-derived human microglia, brain organoids and chimeric mice are overcoming the genetic and environmental ...

New research shows that the Alzheimer's risk gene BIN1 acts as a brake on microglial inflammation, and its loss exaggerates ...

Chronic inhibition of the enzyme soluble epoxide hydrolase with TPPU restored memory, cerebral blood flow, blood-brain barrier integrity, and neuronal ...

Scientists have engineered an MG1 peptide-targeted liposome that delivers aspirin-triggered resolvin D1 to spinal microglia, reprogramming them via a newly ...

A prespecified analysis of the EMPHASIS trial in China finds that minocycline may improve patient-reported quality of life after acute ...

A new mouse study shows that activating the cGAS-STING immune pathway early after spinal cord injury and inhibiting it later ...

A Chonnam National University study found that the human dental pulp stem cell secretome reduced oxidative stress and neuroinflammation while ...

A Swedish study of memory clinic patients finds that lifetime stress exposure is linked to brain amyloid accumulation only in ...

A large analysis of melanoma patients treated with immune checkpoint inhibitors finds that 12 percent develop significant neurotoxicity, often within ...

Researchers have developed a chronic intranasal rotenone mouse model that reproduces the brain-first, olfactory-to-midbrain spread of alpha-synuclein pathology characteristic of ...

A new mouse study shows that four structurally similar dietary flavonoids protect the brain from colitis-related cognitive deficits through distinct ...

A new preclinical study shows that trigonelline, a coffee-derived alkaloid, reduces alpha-synuclein pathology and neuroinflammation in Parkinson's model mice while ...

Scientists have engineered human stem cell-derived spheroids containing myelinating oligodendrocytes and reactive microglia that model demyelination and successful remyelination, offering ...

A comprehensive new review in the Journal of Translational Medicine synthesizes the epidemiology, biology, and treatment controversies of ME/CFS, highlighting ...

A clinical-neuropathological study shows that the lateral sclerosis of ALS reflects a length-dependent dying-back degeneration of upper motor neuron axons, ...

A new review reveals that the dynamic expression of estrogen receptor subtypes across brain development may explain why anesthesia causes ...