Tag: mouse model

A mouse study from Institute of Science Tokyo shows the YAP1–TEAD–TET1 epigenetic pathway can drive hepatocellular carcinoma without canonical driver ...

Cyclic induction of the Yamanaka reprogramming factors for four weeks before stroke reduced ischemic brain damage, preserved neurons and myelin, ...

Engineered probiotic bacteria that release GLP-1 in response to diet showed stronger anti-obesity effects than continuous delivery in obese mice, ...

KIT-led researchers show that inactivating the CD44 molecule reprograms tumor-promoting fibroblasts in pancreatic cancer, reducing fibrosis and immunosuppression and shrinking ...

A ROCK inhibitor partially preserved seminiferous tubule structure and reduced apoptosis in busulfan-treated mice, though sperm parameters remained below control ...

A preclinical mouse study found that Gudan Wan reduced liver injury, inflammation and fibrosis while altering autophagy- and apoptosis-related proteins, ...

Pre-osteoblast-derived migrasomes delivered miR-21a-5p to inhibit osteoclast differentiation in cell assays and reduced bone loss in an ovariectomy mouse model.

A D-configured gold-nanorod and cerium-oxide composite combined near-infrared heating with antioxidant activity to improve infected-wound healing in mice.

A preclinical mouse and hepatoma-cell study found that epinephrine-enhanced expression of the thioredoxin system strengthened chlorpromazine protection against APAP-induced acute ...

Reducing excess asparagine synthetase in a mouse model of Angelman syndrome restored protein synthesis and improved microcephaly and many behavioural ...

A study in diabetic mice with fatty liver found that exercise-linked muscle peptide MOTS-c reduced steatosis through an AMPK–ACE2 pathway.

In a mouse model and cultured mesangial cells, tRF-15:31 reduced oxidative stress and inflammation through an SFRS1-linked mechanism that lowered ...

Ailanthone reduced HSV-1 replication in cell models and eased corneal disease in mice, with experiments implicating reduced expression of the ...

A preclinical mouse study found that Shengjiang San reduced lung inflammation, barrier disruption and neutrophil extracellular trap formation alongside lower ...

In a mouse osteoarthritis model, moderate treadmill exercise altered the gut microbiota, lowered circulating lactate and reduced cartilage damage through ...

A study combining Mendelian randomization with experiments in male mice found that preventive compound probiotics reduced nitroglycerin-induced pain sensitivity and ...

A Schistosoma japonicum-derived microRNA reduced liver fibrosis in carbon-tetrachloride-treated mice alongside lower stellate-cell activation, collagen deposition and inflammatory signaling.

Nicotinamide mononucleotide, or NMN, raised levels of nicotinamide adenine dinucleotide, or NAD+, and reduced signs of spinal cord damage after ...

In a mouse study, postoperative inulin-supplemented enteral nutrition was associated with stronger colonic anastomoses and improved recovery after inflammatory priming, ...

A four-strain probiotic reduced rivaroxaban-associated colonic bleeding and inflammation in mice, with antibiotic disruption suggesting a substantial gut microbiota-dependent contribution.