TMBIM5 Links Calcium Balance to Mitochondrial Quality Control in Liver Disease
Researchers published a study in Cellular & Molecular Biology Letters identifying Transmembrane Bax Inhibitor Motif-containing 5, or TMBIM5, as a ...
Tag: Mitophagy
Researchers Validate Sperm Mitophagy Proteins in Porcine Cell-Free System
Researchers have validated five candidate proteins involved in the targeted degradation of paternal mitochondria following fertilization, utilizing a novel porcine ...
Amyloid beta disrupts mitochondrial ceramide signals and lysosomal stress in Alzheimer’s models
A study in EMBO Reports reports that mitochondrial APP and Aβ40 are associated with reduced CerS1/C18-ceramide accumulation and mitophagy readouts ...
Protein FRZB Restores Bone-Forming Capacity in Periodontal Stem Cells During Inflammation
Researchers have found that overexpressing the protein FRZB restores mitochondrial function and rescues the bone-forming capacity of periodontal ligament stem ...
Alzheimer’s Researchers Propose Mitochondrial PINK1 as an “Amyloid Switch” in Disease Pathogenesis
A new commentary proposes that the mitochondrial protein PINK1, a central regulator of mitophagy, could act as a direct amyloid ...
New ATG4-targeting peptide blocks autophagy and kills cancer cells in mice
A newly designed cell-penetrating peptide that inhibits the autophagy enzyme ATG4 raised reactive oxygen species and significantly reduced tumor size ...
Approved Drugs Dissolve Mutant Polymerase Aggregates and Restore Motor Function in Mice
Two already approved drugs, diltiazem and sulbactam, dissolved mutant POLGA aggregates and restored mitochondrial DNA replication and motor function in ...
Saikosaponin A Shows Promise for Diabetic Wound Healing in Mouse Study
In a preclinical study, saikosaponin A accelerated wound closure in diabetic mice and was associated with suppressed macrophage pyroptosis and ...
NAT10 enzyme drives follicular atresia through ac4C modification of Tnc mRNA
A new study reports that NAT10-catalyzed ac4C modification stabilizes Tnc mRNA, inhibiting mitophagy and driving follicular atresia, with the NAT10 ...
Natural Products Target Mitochondria and Macrophage Crosstalk in Kidney Disease Review
A new review examines how mitochondrial dysfunction and macrophage inflammation interact in diabetic nephropathy and whether natural products can modulate ...
Mitochondrial Cleanup and a DNA Sensor May Team Up to Drive Stroke Inflammation
A new review maps how mitophagy and the cGAS–STING pathway may jointly regulate post-stroke neuroinflammation through leaking mitochondrial DNA, based ...
Ginseng Compound Rg1 Extends Lifespan in Worms Through a DAF-16-Driven Mitophagy Pathway
A new study in Caenorhabditis elegans reports that the ginseng component ginsenoside Rg1 slows aging in the worms by activating ...
Palmitoylation Enzyme ZDHHC5 Emerges as Driver of Neutrophil Inflammation in COPD
A new study links the palmitoyltransferase ZDHHC5 and its modification of NOD2 to neutrophil extracellular trap formation, mitophagy and lung ...
Parkin’s Metabolic Control Emerges as a Key Route to Tumor Suppression
A new open-access review summarizes evidence that the PARK2-encoded E3 ubiquitin ligase Parkin suppresses tumors by regulating mitochondrial function, redox ...
Mitochondria and lysosomes talk to each other, and sepsis may break that conversation
A new narrative review argues that disrupted communication between mitochondria and lysosomes may offer an organizing framework for understanding sepsis-induced ...
Salidroside Protects Bovine Mammary Cells From Inflammation by Activating Mitophagy
A new cell-culture study reports that salidroside protects bovine mammary epithelial cells from LPS-induced inflammatory injury by activating AMPK/mTOR signaling ...
Ancient Chinese Formula Sini Decoction Rewires Immune Cells in Lab Study of Atherosclerosis
A cell study reports that Sini Decoction-containing serum dose-dependently shifted LPS-stimulated macrophages toward an anti-inflammatory state and upregulated NCOR1, though ...
mTORC1 may act as a transition switch in ME/CFS post-exertional malaise
A new review proposes mTORC1 as a transition switch linking mitochondrial dysfunction to post-exertional malaise in ME/CFS, while noting that ...
Traditional Chinese formula blocks liver cancer cell survival by disabling mitochondrial recycling
A preclinical study reports that the herbal formula Xiaoai Jiedu recipe suppresses PINK1-mediated mitophagy and activates NLRP3 inflammasome signaling in ...
Mitochondria Orchestrate Cancer Spread, With Peroxisomes Setting the Rules
A new review argues mitochondria act as mechanometabolic conductors of cancer metastasis while warning that shared peroxisomal machinery complicates drug ...
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