Review assesses tentative gut microbiota and neuroimmune roles in Alzheimer’s disease
A review integrates associative observations in patients with Alzheimer's disease and mild cognitive impairment alongside experimental and animal findings on ...
Tag: mild cognitive impairment
Machine learning finds Non-APOE gene signals too weak to predict Alzheimer’s
A Korean two-stage sequencing study found that Non-APOE candidate variants added almost no predictive power once leakage and APOE effects ...
Beta-brain-wave dips may link amyloid buildup to memory loss in early Alzheimer’s
A resting-state EEG study of amyloid-positive mild cognitive impairment finds that reduced beta-band activity indirectly links amyloid burden to memory ...
Graph Neural Network Maps Local Brain Aging Across the Cortex in Health and Alzheimer’s Disease
A graph neural network trained on more than 14,000 brain scans maps local cortical aging at millimeter resolution and links ...
Triple network effective connectivity imbalance across the Alzheimer’s disease spectrum and its modulation by intermittent theta burst stimulation
A two-cohort neuroimaging study finds default mode network-centered connectivity imbalance across the Alzheimer's disease spectrum and preliminary evidence that intermittent ...
Older Adults with Dementia Stand and Walk Less, Lie Awake Longer, HUNT Study Finds
A Norwegian study of 4,699 adults aged 70 and older found that those with dementia spent about half an hour ...
MRI study maps two sequences of brain barrier leaks and thinning in cognitive impairment
A SuStaIn analysis of DCE-MRI and structural MRI data from 216 participants identified atrophy-first and BBB-first subtypes with distinct cognitive ...
Barriers and facilitators to a physical activity guideline for older adults with mild cognitive impairment
A qualitative study of 33 stakeholders in Shenyang, China, identified 24 barriers and 25 facilitators to implementing a physical activity ...
Cognitive frailty affects nearly four in ten low-income older adults, with sex-specific risk patterns
A cross-sectional study of 255 Malaysian older adults from low-income households found a combined cognitive frailty prevalence of 38.4 percent, ...
Behavioral Changes May Emerge Years Before Cognitive Decline
A study of 11,781 older adults finds that neuropsychiatric symptom trajectories diverge up to 12 years before MCI and 5 ...
Probiotics Show Glimmers of Cognitive Benefit in Dementia Review, but the Evidence Base Is Thin
A systematic review of six randomized trials finds preliminary cognitive gains from probiotics in older adults with existing deficits, while ...
Acupuncture fMRI Findings Across the Alzheimer’s Continuum: What a Critical Review Reveals
A critical review of BOLD-fMRI studies finds acupuncture-related brain network changes across subjective cognitive decline, mild cognitive impairment, and Alzheimer's ...
Subtle cognitive deficits emerge before ALS symptoms appear, study finds
A longitudinal study of people carrying ALS genetic variants found mild cognitive impairment, mainly affecting language and executive functioning, in ...
Tablet-based augmented reality test spots mild cognitive impairment in under 15 minutes
A cross-sectional study of 638 older adults across three countries found that a self-administered tablet-based assessment combining motoric, augmented reality, ...
Donepezil-linked network gains fade as cognition and hippocampus decline
A 36-month retrospective study associated donepezil with early, short-lived brain-network gains but continued cognitive decline and left-hippocampal atrophy in Alzheimer’s-related ...
Three Guduchyadi phytochemicals remain bound in MCI-related protein simulations
A computational study identified 368 putative compounds in Guduchyadi Yoga and modeled persistent binding by three selected phytochemicals to AKT1, ...
AI Listens to Speech to Tell Five Brain Disorders Apart in One Go
A new multimodal AI model from South Korea classifies five neurological language disorders from spontaneous speech while also estimating severity ...
Race, vulnerability and health status shape who receives new Alzheimer’s drugs
A large Michigan Medicine study found that Black and Hispanic adults were far less likely to receive new anti-amyloid Alzheimer's ...
Walking Patterns Reveal Alzheimer’s Risk Differently in Women and Men, Study Finds
A new study of 253 older adults finds that amyloid pathology alters gait and hippocampal structure in sex-specific ways during ...
White Matter Is Not Silent: Hidden Brain Networks Shift Early in Alzheimer’s Disease
A large resting-state fMRI study of 789 ADNI participants shows that white matter functional networks are measurably and selectively disrupted ...
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