Tag: Mendelian randomization

A multivariate genomic analysis has constructed a latent genetic phenotype of adipose tissue aging from seven fat and metabolic traits, ...

A UK Biobank study of 47,537 people identified 213 plasma proteins linked to rheumatoid arthritis onset and built a deep ...

Researchers have identified seven candidate biomarker genes for Parkinson's disease by combining transcriptomic data analysis, Mendelian randomization, and machine learning, ...

A Mendelian randomization and UK Biobank cohort study found that genetically proxied higher bone mineral density was associated with modestly ...

A two-sample Mendelian randomization study using South Asian genetic data found no statistically significant association between genetically predicted vitamin D ...

A large prospective UK Biobank study of 52,584 adults identified nine plasma proteins, led by neurofilament light chain, that predict ...

A comprehensive review finds consistent observational links between H. pylori infection and colorectal neoplasia, but concludes that confounding, inconsistent prospective ...

A combined genetic, cellular, and mouse study finds that semaglutide strengthens gemcitabine's antitumor effect by suppressing RRM1 while weakening methotrexate ...

A study combining Mendelian randomization with experiments in male mice found that preventive compound probiotics reduced nitroglycerin-induced pain sensitivity and ...

A multi-method study prioritized miR-539-3p and SOX9 as linked candidates in keloid tissue and fibroblasts, while leaving their regulatory relationship ...

A local genetic screen linked MST1, DLK1, ITIH1 and SAA1 to intervertebral disc-disorder outcomes, while single-cell tissue analysis and a ...

A study of 792,084 people of European ancestry combined prospective and genetic analyses and linked genetically elevated eosinophil counts to ...

A BMC Cancer abstract reports that public-dataset modeling identified a four-gene prognostic model for prostate adenocarcinoma biochemical recurrence, with supporting ...

A new study combines Mendelian randomization with mouse experiments to link specific gut bacteria, including Parabacteroides goldsteinii and Alistipes shahii, ...

A new study links low vitamin D levels in newborns to higher odds of neonatal sepsis, with genetic analysis offering ...

A landmark genetic study finds that variants in one-carbon metabolism genes, carried on shared East African ancestral haplotypes, help determine ...

The logic underlying Mendelian randomization deserves a closer look, because it explains why the new findings carry more weight than ...

A Mendelian randomization study of 191 brain imaging phenotypes and 1,270 stroke patients finds genetic evidence that triple-network connectivity causally ...

A new narrative review finds that observational studies linking food allergy and ADHD in children are inconsistent and methodologically limited, ...

A large Mendelian randomization study links genetically predicted clonal hematopoiesis of indeterminate potential to increased risks of six cancer types, ...