Tag: Mendelian randomization

An integrated multi-omics study identifies four shared genes and folic acid as a potential therapeutic link between psoriasis and depression.

A Mendelian randomization study of 119 gut microbial genera finds six suggestive inverse associations with non-small cell lung cancer risk, ...

A bidirectional Mendelian randomization study using genetic variants as instruments identifies five microbial taxa with potential causal links to irritable ...

A bidirectional Mendelian randomization study finds no evidence that antibody responses to infections cause Graves' disease, instead linking genetic liability ...

A bidirectional Mendelian randomization study shows that genetic liability to primary biliary cirrhosis causally raises the risk of ulcerative colitis, ...

A multi-cohort transcriptomic, genetic, and experimental study identifies the RHBDF2–ADAM17–TNFα axis as a molecular bridge linking ulcerative colitis to blood–brain ...

An integrated study combining global burden data, Mendelian randomization, multiomics, structural simulation, and cell experiments links PFOS exposure to increased ...

Researchers have developed MRZ, a new Mendelian randomization method that robustly classifies genetic instruments to deliver accurate causal estimates, validated ...

A multi-omics study identifies the mitochondrial pyruvate carrier gene MPC2 as a causal link between hypoxia, mitochondrial energy failure, and ...

A UK Biobank study of over 52,000 adults identifies a 700-protein blood signature that statistically mediates the link between fine ...

A trans-ancestry genome-wide association study of over 16,000 bronchiectasis cases combined with multi-omics analyses has pinpointed SERPINA1 as the strongest ...

Volume 40 of SLAS Technology showcases a smartphone-based colorimetric glucose biosensor using cobalt-nickel nanozymes alongside advances in AI-driven multi-omics, lab ...

A large genomic study of children with cleft lip and/or palate finds that common genetic variants do not explain the ...

A new preclinical study shows that trigonelline, a coffee-derived alkaloid, reduces alpha-synuclein pathology and neuroinflammation in Parkinson's model mice while ...

An integrated analysis of human genetics, patient-derived cell models and electronic health records has identified 19 Alzheimer's drug targets in ...

A meta-analysis of randomized trials combined with Mendelian randomization finds that physical activity improves key aging indicators, with peak benefits ...

An integrated analysis of proteomic data from nearly 90,000 people, single-cell sequencing and molecular docking has identified seven high-confidence drug ...

A large UK Biobank analysis shows that cross-sectional and longitudinal studies yield directionally consistent but systematically different estimates of age-varying ...

A large mendelian randomization study identifies the circulating protein INHBC as a mediator linking Type 2 diabetes to chronic kidney ...

A cross-species study in Nature Aging shows that lipid acyl chains lengthen consistently with age across mice, worms, flies and ...