Tag: Mendelian randomization

An integrative genomic and proteomic study identified seven new genetic loci and 23 genetically supported plasma proteins for age-related macular ...

A Mendelian randomization study finds that ferroptosis-related genes influence acute myeloid leukemia risk directly and indirectly through specific immune cell ...

A new review surveys causal-inference methods applied to Alzheimer's molecular data, finding that many observational associations lack genetic support and ...

A new review synthesizes evidence that metabolic stress may shape DNA methylation through methyl-donor availability, impaired demethylation, and chromatin changes ...

An exploratory genomic framework combining Mendelian randomization, kidney-compartment eQTL data, and colocalization identifies seven candidate genes for kidney traits, with ...

A Mendelian randomization and transcriptomic study identified 11 gut microbial taxa genetically associated with ulcerative colitis and nominated PHLPP2 and ...

A Mendelian randomization study combined with tumor database and cell experiments links genetically higher serum uric acid to lower gastric ...

A Mendelian randomization study of 179 plasma lipids identifies triacylglycerol (50:1) as a genetically associated risk factor for pre-eclampsia, eclampsia, ...

An integrative analysis of blood transcriptomics and genetic data nominally prioritizes SLC51A and TPMT as exploratory candidate diagnostic genes for ...

A UK Biobank study of 181,955 participants links better cardiovascular health and slower biological aging to lower chronic respiratory disease ...

A UK Biobank genetic study finds organ-specific biological age gaps show heterogeneous, direction-dependent genetic relationships with age-related diseases.

A multi-omics Mendelian randomization study identifies HKDC1 and ITGAM as suggestive glycolytic candidates genetically associated with insulin resistance in metabolically ...

A study of more than 21,000 Canadian adults links higher blood pressure to higher intraocular pressure and finds genetic evidence ...

A UK Biobank study of nearly 400,000 adults found that higher triglyceride-glucose index values, especially when combined with waist measurements, ...

A cross-ancestry genomic study identifies shared genetic loci between rheumatoid arthritis and white blood cell traits, highlighting BCL2L11 at 2q13.

A combined epidemiological and genetic analysis finds that genetic susceptibility to higher BMI shows a linear adverse association with mortality, ...

A new method called PRIMA incorporates polygenic risk scores into propensity score matching to help disentangle causal disease relationships from ...

An integrative analysis combining sequencing, Mendelian randomization, tissue cohorts and a luciferase assay identifies miR-183-3p as a candidate ESR1 3′-UTR-binding ...

A combined eQTL and GWAS analysis of cortical and subcortical brain tissues identified 117 genes linked to cognitive performance, with ...

A bibliometric and content analysis of 21,346 Mendelian randomization publications finds horizontal pleiotropy as the most frequently coded methodological challenge ...