Six new pyrazole semicarbazone derivatives were synthesized, characterized spectroscopically, analyzed by DFT calculations, and docked against three carbohydrate-metabolism enzymes, with ...
![Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer's drug design](https://bioengineer.org/wp-content/uploads/2026/10/stackrss-featured-24177-350x250.png)
A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing ...
Chemists report a scalable multistep synthesis of indole–benzimidazole–piperazine carboxamide hybrids, optimized bond by bond and computationally profiled without claims of ...
A new Frontiers in Chemistry review surveys ruthenium-catalyzed C–H activation, annulation, and hydrogen-borrowing strategies for building bioactive heterocycles.
A systematic review of 2020–2025 research highlights piperazine derivatives with potent activity against bacteria, tuberculosis, breast cancer cells and Zika ...
Chemists synthesized arylalkylamine-functionalized alpha-alanine analogues with high stereochemical purity, and two of the new compounds inhibited growth of pathogenic Aspergillus ...
An edited multidisciplinary volume reviews heterocyclic scaffolds, evaluation methods, emerging drug-design approaches and translational challenges in anticancer research.
Newly synthesized fluorinated azabicyclo–benzohydrazone compounds showed stronger-than-standard antibacterial and antifungal activity in laboratory assays, with halogen substitution emerging as the ...
Researchers designed a phenylthioether chalcone compound, B15, that directly binds p38 MAPK and reduced inflammation, oxidative stress and lung tissue ...
A novel series of benzimidazole-based hydrazone derivatives shows significant gastroprotective activity in rats, with compound SH1 achieving efficacy comparable to ...
A study of synthesized ketoprofen–thiazolidin-4-one hybrids found that AR3 reduced mouse paw edema more consistently than ketoprofen at later time ...
KAIST chemists have built an automated platform that combines robots, continuous-flow chemistry and visible light to synthesize drug candidate compounds ...
Researchers have synthesized a series of 1,3,4-oxadiazole derivatives and evaluated their anticancer potential against HS683 human oligodendroglioma cells, identifying one ...
Researchers in Algeria have built an optimized neural network that predicts the analgesic activity of drug-like molecules with 95.9 percent ...
A second-generation library of N,N′-disubstituted aliphatic diamines shows potent, selective activity against multiple Leishmania species, with compounds 12a, 12m, and ...
Computational screening of four halogenated quinoline derivatives identifies QNL1 and QNL3 as promising oral drug candidates against tuberculosis, E. coli, ...
A new review argues that benzothiazole derivatives, acting through DHFR inhibition and heme detoxification, could yield next-generation antimalarials effective against ...
Chemists have converted the anti-inflammatory drug diflunisal into fluorinated biphenyl ureas that kill Mycobacterium kansasii at nanomolar-scale concentrations while leaving ...
Researchers report a one-step skeletal editing reaction that converts readily available oxetanes into thietanes using thiourea, enabling direct oxygen-to-sulfur atom ...
The University of Bath has appointed Professor John Bower, formerly Regius Professor of Chemistry at Liverpool, as the new Raymond ...
