FAPI PET Not Yet Validated for Thyroid Cancer Response
A narrative review indicates that FAPI PET is not yet a validated biomarker for assessing treatment response in radioiodine-refractory differentiated ...
Tag: lenvatinib
Early Blood Pressure and Strain Changes Stratify Cardiovascular Risk in VEGFR-TKI Therapy
A retrospective cohort study of 640 adults found that early changes in blood pressure and cardiac strain provide complementary information ...
MARK2 Enzyme Promotes Stem Cell Characteristics and Drug Resistance in Liver Cancer
Study identifies that MARK2 promotes stem cell characteristics and drug resistance in hepatocellular carcinoma through Wnt and PI3K/AKT signaling.
Dipstick Proteinuria Shows No Clear Survival Link in Hepatocellular Carcinoma
A retrospective cohort study found that dipstick-detected proteinuria was not significantly associated with survival or the addition of immune checkpoint ...
Initial HAIC versus TACE with lenvatinib and PD-1 inhibitors for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective cohort study
A retrospective cohort study found that initial hepatic arterial infusion chemotherapy was associated with longer overall survival and higher response ...
The Relevance of Lenvatinib in Advanced Hepatocellular Carcinoma: Insights from a Prospective Observational Cohort in South India
A prospective cohort study in India demonstrates that first-line lenvatinib provides meaningful survival outcomes and manageable safety in advanced hepatocellular ...
Lenvatinib Restored Radioiodine Uptake in Refractory Thyroid Cancer, Case Report Shows
A case report describes restored radioactive iodine uptake in radioiodine-refractory thyroid cancer after nine months of lenvatinib, enabling salvage radioiodine ...
RPL22 Mutations May Shape Drug Sensitivity in Aggressive Endometrial Cancer
Researchers found RPL22 mutations in 42% of undifferentiated/dedifferentiated endometrial carcinoma samples and showed in cell and xenograft models that the ...
EGFR-IL-8 Feedback Loop Drives Lenvatinib Resistance in Liver Cancer Cells
A new cell-culture study reports that an EGFR-IL-8 signaling loop between liver cancer cells and macrophages sustains lenvatinib resistance in ...
Lower Lenvatinib Starting Doses Show No Clear Advantage in Advanced Endometrial Cancer
A new systematic review and meta-analysis finds that starting lenvatinib below 20 mg with pembrolizumab neither clearly preserves tumor response ...
Triple Therapy Doubles Survival in Advanced Liver Cancer with Portal Vein Clots
A prospective controlled study in BMC Medicine found that adding hepatic arterial infusion chemotherapy to lenvatinib and a PD-1 inhibitor ...
The Fibroblast Problem: Why Liver Cancer Drugs So Often Fail
A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...
Blood Levels of Liver Cancer Drug Lenvatinib Predict Who Responds to Treatment
A multi-omics study of 194 liver cancer patients shows that lenvatinib blood concentrations above 26.5 ng/mL predict treatment response, while ...
Radiomics Predicts Lenvatinib Success in Liver Cancer
In the realm of oncology, the quest for precision medicine has led to intriguing advancements that hold promise for cancer ...
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