Tag: ion channels

A 2026 review in Acta Epileptologica details how KCNT1 gene mutations alter Slack channel function, leading to various forms of ...

Researchers have demonstrated that domestic cat oocytes express functional TRPV3 ion channels whose distinct structural features explain altered pharmacological activation ...

A computational study shows that distinct ion-channel configurations producing the same neuronal activity regimes differ sharply in how much ionic ...

A new mini review details how the lactate receptor HCAR1 modulates neuronal firing across the brain through region-specific ion channel ...

A new review synthesizes evidence that the mechanosensitive channel Piezo1 links abnormal joint loading to inflammatory and catabolic signaling across ...

University of Würzburg professor Georg Nagel shares the 2026 Nobel Prize in Physiology or Medicine for discoveries that enabled light-based ...

Engineered amphotericin B derivatives with improved anion selectivity and reduced cholesterol binding outperform the parent compound as CFTR surrogates in ...

A mouse study links loss of UBE3A to impaired Kv4.2–DPP6 complex remodeling and weakened dendritic channel gradients associated with excitability ...

Three-hour pretreatment with empagliflozin reduced multiple electrophysiological signs of arrhythmia in isolated mouse and rabbit heart cells from two non-ischemic ...

The 2026 Nobel Prize-winning optogenetics technology is now being adapted to probe plant immune signaling, screen novel insecticides, and guide ...

A mechanosensitive channel once thought to detect only physical force turns out to help sensory neurons register burning heat, with ...

Researchers have built and validated a new general-purpose biophysical model of hippocampal CA1 pyramidal neurons that captures a wide range ...

Fifteen years ago, a genetically engineered rhodopsin-based voltage reporter called PROPS captured the first optical recordings of fast membrane-potential transients ...

A new approximate matrix exponential method simulates Markov kinetic models of ion channels an order of magnitude faster and more ...

A new rat study shows that resveratrol slows epilepsy development and protects the hippocampus by restoring SIRT1 signaling and rebalancing ...

Researchers found that rabies virus hijacks the Cav1.2-KCa1.1 ion channel axis to enter cells, and that the FDA-approved calcium channel ...

New research shows that lithium ions competitively block the sodium-dependent activation of eukaryotic fluoride exporter channels, constricting their pores and ...

A new PLOS Biology study shows that the mechanosensitive ion channel Piezo1 allows oligodendrocytes to sense axon diameter and locally ...

New research shows that synthetic lipid nanoparticles trigger irregular calcium signals in cells partly through the pain-sensing ion channel TRPA1, ...

A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...