Tag: immune evasion

A cellular study shows how transcriptionally active defective HIV proviruses can reprogram CD4 T cells through integration-site-specific effects on host ...

A review finds that programmed cell death can promote immune evasion or antitumour immunity in oropharyngeal cancer depending on pathway ...

A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, ...

New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.

Researchers at Radboud University Medical Center report that prolyl hydroxylation of Zika virus NS1 is essential for the protein's maturation ...

A new study reveals that PRKDC, a gene known for DNA repair, drives immune evasion in hepatocellular carcinoma by pushing ...

A new study shows that cancer cells selectively erode gene-rich regions of the Y chromosome, disrupting regulatory pathways and opening ...

A new review in Med Research redefines protein glutamylation as a versatile signaling-related post-translational modification with roles in immunity, development, ...

A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...

A machine learning analysis of inflammation and metabolism genes across seven lung adenocarcinoma cohorts identifies the calcium pump gene ATP2A2 ...

A new review explains why BCG immunotherapy fails in some bladder cancer patients and outlines emerging combination strategies designed to ...

Osteosarcoma has long frustrated oncologists. It is the most common primary malignant bone tumor, striking hardest in adolescents, and while ...

A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...

A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic ...

Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...

New research shows the chromatin organizer Satb1 enables regulatory T cells to promote tumor growth while remaining dispensable for preventing ...

A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...

New research reveals that the ubiquitin ligase BTRC destroys the RNA-binding protein hnRNPC, whose stabilization of PSD4 mRNA boosts PD-L1 ...

New research in PLOS Biology defines the titanide, a tiny stress-resistant cell type that Cryptococcus neoformans generates from typical yeast ...

A 2023 severe hand, foot and mouth disease outbreak in Vietnam was caused by a single introduction of enterovirus A71 ...