A cross-sectional investigation reveals that individuals with pure motor amyotrophic lateral sclerosis exhibit measurable deficits when discriminating negative facial emotions ...
A comprehensive scientific review shows that motor neuron degeneration in ALS and FTD arises from a systemic logistical collapse driven ...
A study in a progranulin knockout mouse model of frontotemporal dementia links aging, lysosomal dysfunction, and synaptic deficits to progressive ...
Enhancing glycolysis restores bioenergetics and improves survival in Drosophila and human neuronal models of MAPT-related frontotemporal dementia.
A preclinical study found that six weeks of candesartan administration did not modify tau pathology, receptor levels, or neuroinflammatory markers ...
Researchers report that the ALS-linked kinase TBK1 clears aggregation-prone monomeric TDP-43 in neurons by inducing interferon-β and the immunoproteasome, an ...
A Drosophila study shows that expressing expanded C9orf72 G4C2 repeats in mushroom body neurons drives age-dependent TDP-43 mislocalization, synaptic loss ...
A prospective Finnish cohort study finds that sleep disturbance profiles differ across early-stage Alzheimer's disease, behavioral variant frontotemporal dementia and ...
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
A prospective neuroimaging study finds that atrophy patterns across frontotemporal dementia syndromes spatially align with maps of neurotransmitter receptor expression.
A mouse study finds that progranulin deficiency impairs cathepsin D enzymatic activity despite elevated protein levels, disrupts lysosomal organization, and ...
A translational overview argues that pathological decision-making is a measurable neurological failure spanning glutamate signaling, stress-driven eating, dementia, impulsivity and ...
A longitudinal study of people carrying ALS genetic variants found mild cognitive impairment, mainly affecting language and executive functioning, in ...
A matched PET and post-mortem study links elevated TSPO binding in frontotemporal dementia primarily to a greater burden of CD68-positive ...
Northwestern University researchers have identified a single water-defined hotspot on tau proteins that drives the misfolding cascade behind Alzheimer's and ...
A UCL and University of Surrey collaboration has systematically characterised sleep disturbance in the temporal lobe variants of frontotemporal dementia, ...
A new explainable machine learning framework combining EEG signals with clinical data distinguishes Alzheimer's disease from frontotemporal dementia with 89.8 ...
A large international validation study confirms that apathy, reduced conscientiousness, and frontal lobe shrinkage together explain everyday disability in early-stage ...
Advanced MRI has revealed the first consistent brain signature of the ultra-rare neurological disorder FOSMN, showing brainstem atrophy and damage ...
