Tag: epigenetics

An international team has developed OpenCGChromatin, an open-source simulation tool that acts as a computational microscope to reveal how chromatin ...

Aging May Stem From a Genome-Wide Shift That Sidelined Cellular Maintenance

A new GeroScience study finds that after sexual maturity, housekeeping genes lose transcriptional share to specialized integrative genes across species, ...

How Genes, Hormones and Weather Decide When a Flower Blooms

A sweeping review explains how MADS-box genes, microRNAs, hormones and environmental signals jointly control flowering, floral organ identity and sex ...

Hidden Genome Folds Silence Two Tumor-Suppressing Genes in Aggressive Breast Cancer

Researchers have discovered that DNA methylation evicts the architectural protein CTCF from the HOXD locus, collapsing a chromatin loop that ...

Faulty Epigenetic Switch Disrupts Brain Cell Cycles and Drives White Matter Defects in Autism-Linked Disorders

New research shows that pathogenic variants in the chromatin regulator MSL2 disrupt oligodendrocyte precursor cell division and myelination through loss ...

Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target

A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem ...

Blood Test Reads DNA Methylation Patterns to Help Detect Deadly Esophageal Cancer

A large two-cohort study shows that a blood-based DNA methylation panel targeting the HYAL2, S100P and DYRK4 genes, combined with ...

Metabolic Switch in Heart Cells Rewinds Injury Into Regeneration, Study Finds

New research shows that transient inhibition of the mitochondrial enzyme succinate dehydrogenase triggers coordinated metabolic and epigenetic reprogramming across heart ...

Estrogen receptor fuels breast cancer growth through an RNA-tagging loop, study finds

New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the ...

Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure

A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...

Diseased Kidneys Age Faster at the Cellular Level, Single-Cell Epigenome Atlas Reveals

A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...

Common Antibiotic Calms Children’s Wheezing by Rewriting Inflammatory Memory in Lung Immune Cells

A new study shows azithromycin eases post-inflammatory wheezing in children by inhibiting SETD1B-driven H3K4me3 methylation and rebalancing macrophage polarization in ...

Genes and Epigenetics Converge to Explain Sudden Cardiac Death Without Family History

October 7, 2026

A new review maps how common genetic variants, insertion/deletion polymorphisms, microRNAs, DNA methylation and histone modifications together shape the risk ...

NIH Backs Bold Epigenetics Quest to Decode How Immune Cells Walk the Tightrope Between Defense and Disease

Van Andel Institute's Dr. Derek Janssens has received a nearly $4.6 million NIH New Innovator Award to develop tools that ...

First Mosaic Case Rewrites the Genetic Story of a Rare Overgrowth Syndrome

Researchers report the first known case of Cohen–Gibson syndrome caused by a mosaic EED variant, expanding the mutational spectrum of ...

Hidden DNA Rings and a Rogue Gene Reveal Ovarian Cancer’s Adaptive Defense

A new study links HDAC inhibitor treatment to remodeling of extrachromosomal circular DNA in ovarian cancer and identifies LMO2 as ...

Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds

A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...

Crushing Rice Seeds Under Pressure Leaves Genetic Scars That Last Nine Generations