Tag: epigenetics

A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...

A comprehensive review in Diabetes Therapy maps the bidirectional relationship between diabetes and cancer, positioning epigenetic dysregulation as the molecular ...

A new review in Molecular Biology Reports argues that DNA methylation silencing of the TRAIL pathway components DR5, DcR2, and ...

Researchers at Sanford Burnham Prebys report that temporarily blocking the metabolic enzyme succinate dehydrogenase triggers an epigenetic switch in mouse ...

A Nature Communications study shows that loss of the SWI/SNF subunit SMARCD1 drives clear cell renal cell carcinoma through a ...

New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of ...

A Vanderbilt-led team sequencing the genome and epigenome of Jonathan, a 194-year-old giant tortoise on St. Helena, found that promoters ...

A new study shows that the dual EZH1/2 inhibitor valemetostat counteracts HTLV-1-induced epigenetic changes in retinal cells and suppresses viral ...

A paired-sample study of 38 melanoma patients reveals that metastases undergo coordinated DNA methylation reprogramming largely independent of driver mutations, ...

A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...

Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking ...

A Johns Hopkins study shows chronic cigarette smoke exposure reprograms distinct lung stem cell populations through epigenetic changes, determining whether ...

University of Bonn researchers directly reprogrammed red blood cell precursors from elderly donors into neural stem cells whose epigenetic clocks ...

New research shows that silencing the PD-L1 gene in gastric cancer cells reshapes the expression of MAPK-regulating DUSP phosphatases, revealing ...

New research shows that restoring the microRNAs miR-34a and miR-34c suppresses the survival, migration, invasion, and stemness of pediatric grade ...

New research shows that diabetes elevates the histone mark H3K4me1 in pancreatic acinar cells, driving stress granule formation under high ...

A two-stage epigenome-wide meta-analysis of more than 2,000 individuals has identified thousands of DNA methylation sites where Parkinson's disease affects ...

A large-scale study of 864 dogs finds that giant breeds lose methylation control over LINE1 jumping genes far faster than ...

A new PLOS Genetics study shows that the RNA modification enzyme METTL1 controls hair follicle cycling by stabilizing HOXC13 messenger ...

A self-reinforcing injectable hydrogel converts body movement into electrical signals that trigger calcium-dependent histone acetylation and accelerate bone regeneration in ...