Researchers mapped Alzheimer's disease heterogeneity across bulk, single-nucleus, and spatial transcriptomics using a neural pathway unsupervised learning framework.
Researchers identified phosducin-like protein 2 as an essential antioxidant that coordinates physiological reactive oxygen species dynamics during sperm morphogenesis.
A review proposes that PARP1 dynamically interprets DNA lesion geometry and chromatin context rather than operating as a uniform damage ...
A genome-wide study of free-breeding dogs living within the Chernobyl Exclusion Zone reveals that canines at the nuclear plant and ...
Researchers using saturation genome editing across cell types found that mammary cells can buffer some BRCA1 mutations, helping distinguish high-risk ...
A study using human TK6 cell lines reveals that tyrosyl-DNA phosphodiesterase 2 provides critical backup repair for DNA double-strand breaks ...
A new study reveals that human cells deficient in the FANCD2 protein are significantly more sensitive to the genotoxic effects ...
A new study reveals that fumarate accumulation in kidney cancer cells impairs DNA repair by modifying the RPA1 protein, leading ...
A study in Cellular and Molecular Neurobiology identifies hippocampal senescence-like alterations in a maternal deprivation rat model, linking them to ...
High-speed atomic force microscopy has revealed how the Smc5/6 protein complex changes shape, captures DNA and tethers separate DNA strands ...
A case-control study of Egyptian patients links OGG1 and CYP1A1 gene variants to increased pancreatic adenocarcinoma risk and identifies CYP1A1 ...
A study in human cells reveals that the DNA repair enzyme MUTYH triggers untargeted action-at-a-distance mutations along the damaged strand ...
Researchers propose that alcohol drives cancer not merely as an isolated carcinogen, but as an amplifier interacting with the broader ...
A preclinical study shows that ionizing radiation induces a transient glutamine dependency in triple-negative breast cancer that can be targeted ...
A computational pan-cancer analysis links overexpression of the RPA gene family to worse survival and an immunosuppressive tumor microenvironment in ...
A new narrative review synthesizes how the multifunctional protein JWA intersects with redox homeostasis across cancer, neurodegeneration and tissue injury, ...
A gene set enrichment analysis of 178 strong-evidence male infertility genes reveals overrepresentation of ciliary, endocrine, and DNA repair pathways ...
Extracellular vesicles from the medicinal fungus Antrodia cinnamomea suppressed hepatocellular carcinoma cell proliferation, migration and invasion in laboratory assays, apparently ...
DNA damage triggers tubulin acetylation that displaces the perinuclear vimentin cage, allowing microtubule forces to ripple the nucleus and speed ...
Researchers report that the RNA-processing protein ALYREF binds poly-ADP-ribose at DNA double-strand breaks, delaying repair when overexpressed and marking a ...
