Tag: DNA damage response

An international expert workshop has prioritised targets and trial designs to break the three-decade therapeutic stalemate in desmoplastic small round ...

A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...

A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...

A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...

A new review in Molecular Cancer reframes radioresistance as an ecosystem-level phenomenon in which plastic residual tumor cells survive radiation ...

A Phase 1 trial found that combining the ATR inhibitor ceralasertib with the PARP inhibitor olaparib was generally well tolerated ...

New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...

New research in C. elegans shows that the FOXO transcription factor DAF-16 directly activates DNA repair genes to preserve genome ...

Transcription is a vital cellular process orchestrated by RNA polymerase II (Pol II), enabling the expression of genes that drive ...