Tag: DNA damage response

HeLa cells develop resistance to the thymidine analogue EdU by downregulating the SLC22A17 transporter and entering a state of transcriptomic ...

Inhibiting IGF-1R reduces myelodysplastic syndrome cell proliferation, triggers DNA damage, and sensitizes malignant cells to natural killer cell destruction via ...

An international scientific review delineates how distinct chemotherapy agents and radiation therapy trigger divergent DNA damage, cGAS–STING signaling, ferroptotic, and ...

A review in Discover Oncology details how Notch signaling pathways drive cancer drug resistance through mechanisms involving apoptosis, DNA repair, ...

A review in Cellular Oncology examines how human single-stranded DNA-binding proteins hSSB1 and hSSB2 coordinate DNA repair pathways and preserve ...

Researchers discover that the enzyme DPP9 promotes temozolomide resistance in glioma by controlling RFWD3 nuclear localization and sustaining RPA1 stability.

Unbiased Cas12a combinatorial knockout screens across 233 genes have mapped synthetic lethal and buffering interactions across the DNA damage response ...

A new ex vivo platform derives temozolomide- and radiation-selected glioblastoma stem-like cells from the same primary tumor, exposing mismatch-repair loss, ...

Researchers used optogenetic melanopsin stimulation in HeLa cells to show that the timing pattern of light-evoked calcium signaling selectively shapes ...

A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...

In the plant pathogen Fusarium mangiferae, ultraviolet C radiation significantly increases ribosome levels and translation capacity in filaments, and blocking ...

An editorial summarizing eight contributions describes cancer drug resistance as an adaptive process involving genetic, epigenetic, metabolic, signalling and microenvironmental ...

Network analysis and B16F0 cell experiments linked carboplatin with CDKN1A, BRCA1, PTEN and AKT1 in melanoma, without establishing clinical benefit.

A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...

New research shows that the transcription factor C/EBPβ normally restrains an inflammatory interferon and TNF-α program that, when unleashed in ...

A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...

A new GeroScience study shows that the dietary polyphenol chlorogenic acid protects aging intestinal stem cells from oxidative stress in ...

A new multi-omics framework proposes that tumor immunogenicity emerges only when epigenetic permissiveness, DNA damage response configuration and immune activation ...

A new PLOS Pathogens study shows that human cytomegalovirus induces and recruits the host chromatin remodeler MORC2 to viral replication ...

An international expert workshop has prioritised targets and trial designs to break the three-decade therapeutic stalemate in desmoplastic small round ...