Tag: Chromatin accessibility

A new study in The EMBO Journal reveals that the cancer-linked gene E2F1 can trigger cell division via a shortcut ...

A new study shows that SMARCAL1 forms nuclear condensates that reprogram chromatin and methionine metabolism, weakening radiotherapy and immunotherapy responses.

A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those ...

A population-scale single-nucleus study of 287 human skeletal muscle biopsies maps cell-type-specific eQTLs and caQTLs that colocalize with thousands of ...

An integrative ATAC-seq and RNA-seq study of induced endothelial cells from capillary malformation patients identifies inflammation-associated chromatin remodeling and distal ...

A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...

A computational benchmarking study found that SubPoE delivered the strongest average spatial-domain clustering results across eight paired spatial multi-omics datasets ...

A comparative study in two beetle species links evolving regulatory DNA and condition-specific chromatin changes to horn diversification, with functional ...

A mouse study found that embryonic thalamic progenitors segregate into sensory and motor-associative lineages, with Sp9 perturbation reducing formation of ...

A mini-review finds that AI-assisted reconstruction of cell-state-specific gene regulatory networks can illuminate tumor plasticity and drug resistance, but experimental ...

A combined single-nucleus and spatial ATAC-seq study maps grade-associated chromatin regulatory programs in non-functional pancreatic neuroendocrine tumors, revealing spatially organized ...

A new research topic in Frontiers in Cell and Developmental Biology brings together studies on zygotic genome activation, epigenetic reprogramming, ...

A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...

Researchers discovered that the RNA-modifying enzyme PUS7 pseudouridylates the noncoding RNA 7SK to recruit the BAF chromatin-remodeling complex, enabling a ...

A new review synthesizes single-cell chromatin accessibility studies showing that colorectal cancer is organized into two epigenomic states whose regulatory ...

A new single-cell and spatial atlas of the developing human face identifies 56 cell states, hundreds of spatial patterning genes ...

A single-cell chromatin accessibility atlas of the human intestine maps regulatory programs across 29 cell types and shows that Crohn's ...

In a landmark advancement in the field of genomics, researchers have unveiled a novel technique known as Genomic loci positioning ...

In a groundbreaking development within the field of genomics, researchers have unveiled a novel approach to enhancing the quality of ...

In a groundbreaking advancement within the realm of cellular biology, researchers have developed a novel technique called ISSAAC-seq, which allows ...