A comprehensive scientific review details how natural polysaccharide nanocarriers remodel the immunosuppressive liver tumor microenvironment by repolarizing macrophages, activating innate ...
Researchers have identified TRPM7 as a critical driver of chondrocyte senescence and osteoarthritis progression through a PDK4-mediated organelle tethering and ...
The novel PARP inhibitor No. 123 suppresses cervical cancer progression in preclinical models through a dual mechanism of direct cytotoxicity ...
A narrative review outlines an evidence-to-decision framework evaluating how neurovascular unit dysfunction contributes to diabetic retinopathy beyond conventional microvascular lesions.
A comprehensive scientific review outlines how metabolic strain during high-intensity interval training may cause mitochondrial DNA leakage that engages innate ...
A study in mice reveals that L-menthol reduces brain damage and neuroinflammation following intracerebral hemorrhage by suppressing microglial cGAS-STING signaling ...
A comprehensive literature review reveals how dengue virus evades host pattern recognition receptors and manipulates cell death pathways to cause ...
A scientific review outlines how copper-induced mitochondrial proteotoxicity could trigger innate immune sensing to counteract immunosuppressive microenvironments in glioblastoma.
A new study shows that hESC-MSC-EVs reduce brain injury after cardiac arrest by inhibiting cGAS/STING-mediated neuronal pyroptosis.
Inhibiting SERPINE1 suppresses cGAS-STING-driven fibroblast senescence and relieves intestinal inflammation in experimental models of Crohn’s disease.
A narrative review synthesizes evidence showing mitochondrial dysfunction amplifies senescence-associated secretory signaling through context-dependent innate immune sensing rather than serving ...
A review in Clinical and Experimental Medicine examines how mitochondrial metabolism and signalling govern tumour immune evasion and highlight potential ...
In a mouse model of abdominal aortic aneurysm, the STING inhibitor C-176 reduced aneurysm incidence, limited aortic dilation, and suppressed ...
Researchers have engineered a zinc peroxide-coated gold nanorod that combines photothermal heating, self-supplied chemodynamic radicals, and zinc-driven cGAS-STING immune activation ...
A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...
A new study shows that the RNA cap-modifying enzyme PCIF1 drives tumor growth and radioresistance, and that removing its m6Am ...
A new mouse study shows that activating the cGAS-STING immune pathway early after spinal cord injury and inhibiting it later ...
Activating the antioxidant regulator NRF2 suppresses STING-driven inflammation in obese fat tissue, but the effect differs sharply between visceral and ...
Researchers have built a cancer-cell-membrane-coated manganese dioxide nanosheet that delivers the immune adjuvant R848 directly to tumors, relieving hypoxia and ...
A new review argues that antibody–drug conjugates act as immune modulators through immunogenic cell death, Fc-mediated effector functions and tumour ...
