Pancreatic cancer review maps how pyroptosis, ferroptosis and anoikis resistance interact
A new review in Cell Communication and Signaling examines how three forms of regulated cell death interact in pancreatic ductal ...
Tag: Cell Death
Smurf1 Knockdown Drives Liver Failure via Ferroptosis
A new study reveals that knocking down the protein Smurf1 promotes ferroptosis in acute liver failure by stabilizing Ulk1 and ...
DAPK1–Lipin1 fatty acid oxidation axis exposes ferroptosis vulnerability in colorectal cancer
Researchers found that the kinase DAPK1 stabilizes Lipin1 to boost fatty acid oxidation, raising lipid peroxidation and making colorectal cancer ...
SUMO protein tags may shape organ damage in sepsis, review finds
A new review links SUMOylation and deSUMOylation to inflammatory signalling, immunometabolic adaptation and organ injury in sepsis while cautioning that ...
Perforin Kills Cancer Cells Alone, Without Granzymes, Study Finds
New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...
Scientists identify Tollip as a brake on plasma membrane repair
A new study identifies Tollip as a conserved negative regulator of ESCRT-III-mediated plasma membrane repair, showing that the protein balances ...
CISD2 knockdown suppresses gastric cancer and triggers ferroptosis
Knocking down CISD2 suppresses gastric cancer cell growth and induces ferroptosis through inhibition of the mTOR/SREBF1/SCD1 axis and GPX4 downregulation, ...
Periplocin Kills Osteosarcoma Cells by Driving Necroptosis and Pyroptosis
A new Biology Direct study shows that periplocin suppresses osteosarcoma cell proliferation and tumor growth in preclinical models by inducing ...
Glucose withdrawal triggers disulfidptosis-like cell death in diabetic retinopathy vessels
Researchers report that SLC7A11 upregulation in diabetic retinopathy vessels creates a glucose dependency that can be exploited to trigger disulfidptosis-like ...
Scientists discover a durable molecular fingerprint of ferroptosis in cells and blood
A reducing reagent-resistant dimer of transferrin receptor 1 emerges during lipid peroxidation and can be detected in tissues and blood-borne ...
Cell stress sensors ATF4 and ATF6 steer how lung cancer cells cope with glucose starvation
A new study shows that the stress sensors ATF4 and ATF6 coordinate transcriptional and metabolic responses to glucose deprivation in ...
Unraveling the iron grip: ferroptosis and its role in cardiovascular diseases
A new open-access review in Cell Biology and Toxicology examines how ferroptosis, an iron-dependent form of cell death, may contribute ...
Excess cysteine releases iron, overwhelming mitochondria and killing cells
A CRISPR screen and laboratory experiments show that excess cysteine releases iron from ferritin, damages mitochondria and triggers cell death.
ASPHD1 links adaptive kidney-tubule states to cell-death vulnerability
Human kidney transcriptomics associated ASPHD1 with adaptive proximal-tubule states, while cell experiments found that silencing it increased apoptosis- and ferroptosis-associated ...
Targeting pyroptosis in intestinal and systemic inflammatory diseases: mechanisms and therapeutic opportunities
A 2026 review identifies pyroptosis as a context-dependent pathway in intestinal and systemic inflammation and evaluates inflammasome, caspase and gasdermin-directed ...
LX-2 hepatic stellate cells alter 3D HepG2 hepatocellular carcinoma spheroids and are associated with lower sorafenib sensitivity
An in vitro 3D cell-line study found that adding LX-2 hepatic stellate cells to HepG2 hepatocellular carcinoma spheroids was associated ...
Hidden RNA Structures in Pancreatic Cancer Cells Reveal New Drug Vulnerability
New research reveals that NEAT1-built nuclear structures called paraspeckles determine both the identity of pancreatic cancer cells and their resistance ...
Copper Overload Triggers a Distinct Form of Cell Death That Could Transform Cancer Therapy
A new review details how excess copper induces cuproptosis, a mitochondria-dependent form of cell death that cancer cells are uniquely ...
The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Tiny Pores or Total Rupture: How Lysosome Damage Decides Whether Cells Die by Apoptosis or Necrosis
A new review argues that lysosomal membrane permeabilization and lysosomal membrane rupture are mechanistically distinct failures that determine whether cells ...
