From Glycans to Mitochondria: Women Scientists Map the Frontiers of Cell Death Research
A new Frontiers in Cell Death Research Topic curated by women scientists collects five studies spanning necroptosis, death receptor glycans, ...
Tag: Cell Death
Somatic Cells Kill Germline Cysts by Acidification, Review Finds
A new review synthesises evidence that somatic support cells eliminate germline cysts in flies and mice through a conserved non-apoptotic ...
Cell-death proteins in the blood track severity of wasp sting poisoning
When hornets and wasps attack in swarms, the consequences can be far more dangerous than a painful welt. Severe Hymenoptera ...
Copper Cell Death Emerges as a Hidden Driver of Acute Kidney Injury
A new study identifies cuproptosis as a major regulated cell death pathway in ischemic acute kidney injury and shows that ...
Tiny Protein G0S2 Emerges as a Master Switch for Cell Death in Liver Cancer
A new proteomic study reports that the small protein G0S2 promotes apoptosis through the BAX/Caspase3 pathway, positioning it as a ...
Crushed by Crowding: Tumor Pressure Triggers Cancer Cell Self-Destruction, Study Finds
New research shows that sustained mechanical confinement inside densely packed tumors activates necroptosis in migratory cancer cells, halting metastasis and ...
Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
Betel Nut Chemical Shields Oral Cancer Cells From Copper-Driven Cell Death
New research shows that arecoline, the main alkaloid in betel nut, activates a ROS-NRF2-MT2A signaling axis that protects oral squamous ...
Copper Cell Death Pathway Uncovered as Driver of Blindness-Causing Retinal Injury
A new study in Cell Death Discovery shows that the copper-binding protein metallothionein 3 regulates cuproptosis in retinal ischemia–reperfusion injury ...
Diabetes Drug Metformin Surprisingly Blocks Ferroptotic Cell Death in Cancer Cells
New research shows that metformin and phenformin suppress cysteine deprivation-induced ferroptosis in cancer cells by dampening mitochondrial hyperpolarization, oxygen consumption, ...
Triaptosis: Scientists Unveil a New Form of Cell Death Centered on Endosomes
A new review in Cell Death & Discovery proposes triaptosis, an endosome-centered form of ROS-regulated cell death driven by oxidative ...
Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
Spermidine Shields Ovarian Cells From Copper-Triggered Cell Death, Study Finds
New research shows that the natural polyamine spermidine protects pig ovarian granulosa cells from copper overload-induced cuproptosis by suppressing miR-194a-5p ...
Cell Death Genes Could Predict Survival in Esophageal Cancer, Study Finds
Researchers built a five-gene PANoptosis-based risk model and nomogram that predict survival, immune landscape, and treatment sensitivity in esophageal cancer ...
ALDH2’s Role in Autophagy and Cell Death
In recent studies, the enzyme aldehyde dehydrogenase 2, commonly known as ALDH2, has emerged as a critical player in the ...
