DNA Methylation Patterns Predict MDS Treatment Response
A new multicenter study finds that DNA methylation patterns at diagnosis can predict which MDS patients will respond to azacitidine, ...
Tag: cancer research
Preclinical Meta-Analysis Evaluates Escin and Nanoformulations Against Cancer Growth
A systematic review of 34 preclinical studies indicates that escin and its nanoformulations significantly inhibit cancer cell growth and reduce ...
N-Myc Drives Basal Cell Carcinoma Progression by Enforcing a Progenitor State
Researchers discover that the oncogene N-Myc fuels basal cell carcinoma growth by sustaining an undifferentiated progenitor state susceptible to imiquimod-induced ...
WDR54 Drives Head and Neck Cancer Progression by Stabilizing SLC43A3
Researchers have identified that WDR54 drives head and neck squamous cell carcinoma progression by stabilizing the fatty acid transporter SLC43A3, ...
Real-World French Study Evaluates First-Line Olaparib Combination in Advanced Prostate Cancer
A descriptive analysis of 154 patients enrolled in the French funded Early Access program confirms the real-world safety and dosing ...
Enzyme USP3L Promotes Gastric Cancer Progression Through a Hippo Signaling Feedback Loop
Researchers found that deubiquitinase USP3L stabilizes YAP and accelerates gastric cancer progression through a reciprocal positive feedback loop.
Long-Term Study Reveals Striking Clinical Heterogeneity in Rare Cutaneous T-Cell Lymphoma
A twenty-year retrospective study at Samsung Medical Center reveals that primary cutaneous gamma-delta T-cell lymphoma exhibits substantial clinical heterogeneity, with ...
Benchmark reveals privacy trade-offs in synthetic RNA-seq models
A new benchmark in Genome Biology evaluates eleven generative models for synthetic bulk RNA-seq data, revealing significant trade-offs between predictive ...
Ludwig and Keystone Announce 2027 Cancer Metabolism Meeting
The Ludwig Institute for Cancer Research and Keystone Symposia have announced a joint meeting on tumor and host metabolism to ...
Demethylzeylasteral Suppresses Mammary Tumor Growth by Modulating MDM2-p21 Signaling
Researchers demonstrated that the triterpenoid demethylzeylasteral induces G1 phase arrest and mitochondrial apoptosis in breast cancer models through modulation of ...
Cancer Gene E2F1 Bypasses Standard Rules to Trigger Cell Division
A new study in The EMBO Journal reveals that the cancer-linked gene E2F1 can trigger cell division via a shortcut ...
Harvard Team Wins $7M Grant for AI Cancer Research
A Harvard Medical School team led by Marinka Zitnik has received a nearly $7 million grant from Cancer Grand Challenges ...
Fra-1 Promotes Thyroid Cancer Progression via YWHAH and Pentose Phosphate Pathway
Researchers have found that Fra-1 drives thyroid cancer progression by binding the YWHAH promoter and activating the pentose phosphate pathway.
Pancreatic Cancer Study Uncovers Biological Differences Across Diverse Patient Populations
Researchers have identified distinct tumor molecular signatures and immune cell profiles in pancreatic cancer between Black African American and Non-African ...
Maslinic acid neuroblastoma study retracted over figure concerns
The Editor-in-Chief of AMB Express has officially retracted a 2020 article investigating the anticancer effects of maslinic acid in human ...
Basket Trial Evaluates Oral Ponatinib for Solid Tumors With Genomic Alterations
A phase 2 basket trial found oral ponatinib did not meet its primary endpoint in solid tumors with FGFR alterations, ...
Subcellular RNA Patterns Improve Cell Clustering in Spatial Transcriptomics
A new graph autoencoder framework called SPICEiST enhances cell clustering in imaging-based spatial transcriptomics by integrating subcellular RNA patterns with ...
Study Links TMC8 Protein to Clear Cell Renal Cell Carcinoma Tumor Progression
Researchers found that elevated TMC8 expression in clear cell renal cell carcinoma correlates with poor survival, paradoxical immune infiltration, and ...
Study Links Venetoclax to AK2 in Glioma
A study in Cell & Bioscience identifies AK2 as a key metabolic and immune-related factor in gliomas, with Venetoclax showing ...
Reprogramming Tumor Cells into Dendritic Cells Promotes Antitumor Immune Structures
Researchers have demonstrated that reprogramming cancer cells into dendritic cells promotes tertiary lymphoid structures that help coordinate antitumor immune responses ...
