Study Links TMC8 Protein to Clear Cell Renal Cell Carcinoma Tumor Progression
Researchers found that elevated TMC8 expression in clear cell renal cell carcinoma correlates with poor survival, paradoxical immune infiltration, and ...
Tag: cancer research
Study Links Venetoclax to AK2 in Glioma
A study in Cell & Bioscience identifies AK2 as a key metabolic and immune-related factor in gliomas, with Venetoclax showing ...
Reprogramming Tumor Cells into Dendritic Cells Promotes Antitumor Immune Structures
Researchers have demonstrated that reprogramming cancer cells into dendritic cells promotes tertiary lymphoid structures that help coordinate antitumor immune responses ...
Novel Compounds Target Cell Division Checkpoint in Drug-Resistant Glioblastoma
Researchers at the Indian Institute of Technology Gandhinagar have developed two compounds that suppress drug-resistant glioblastoma cells by blocking the ...
Cell-Penetrating TRIM21 Degrader Destroys Pan-PIM Kinases in Breast Cancer Cells
Researchers have engineered a cell-penetrating TRIM21-based protein degrader that targets all three PIM kinase isoforms to induce apoptosis in breast ...
Cachexia Gene Signature Predicts Colon Cancer Outcomes
A new cachexia-related gene signature independently predicts prognosis and immune infiltration in colon adenocarcinoma, identifying MAPK12 as a potential therapeutic ...
HNRNPAB Promotes Glioblastoma Cell Proliferation by Stabilizing EZH2 mRNA in Study
Researchers identified HNRNPAB as a driver of glioblastoma cell proliferation that directly stabilizes EZH2 mRNA to activate oncogenic PI3K-AKT-mTOR and ...
Targeting RBM39 Disrupts Mitosis and Sensitizes Triple-Negative Breast Cancer Cells
In triple-negative breast cancer cell lines and organoids, pharmacologic targeting of the splicing factor RBM39 disrupts mitotic fidelity and increases ...
Integrated PET and MRI Imaging Maps Molecular Targets in High-Grade Sarcomas
A pilot study evaluating integrated PET and MRI revealed that molecular tracer uptake strongly correlates with cellular density and immunohistochemical ...
Study Uncovers How Basophils Restrain Regulatory T Cells to Inhibit Metastasis
Researchers have discovered that basophils suppress early lung metastatic seeding by curbing regulatory T cells through histamine signaling and enzymatic ...
Psycho-oncology trials largely ignore sex and gender reporting standards, review finds
A systematic review of 404 psycho-oncology randomized controlled trials found that more than half misused sex and gender terminology and ...
NRF2 Regulates Ferroptosis Vulnerability and Immune Responses in Endometrial Cancer Models
Researchers found that NRF2 regulates inflammatory adaptation, ferroptotic vulnerability, and interferon-gamma immune signaling across endometrial carcinoma models and clinical datasets.
Review Identifies ATG5 as Context-Dependent Switch in Cancer Drug Resistance
A scientific review published in Cancer Cell International highlights ATG5 as a context-dependent molecular switch driving therapy resistance and survival ...
Advillin protein stabilizes YAP to drive rhabdomyosarcoma growth
Researchers report that the actin-binding protein advillin stabilizes the transcriptional regulator YAP to sustain oncogenic growth in rhabdomyosarcoma, and that ...
Linalool Shows Multi-Target Anticancer Activity, But Clinical Translation Remains Distant
A new review finds the volatile plant monoterpene linalool suppresses multiple cancer types through several molecular pathways, while nanoformulations may ...
New ensemble tool sharpens chromatin interaction calls in 4C-seq data
A weighted-voting ensemble called fourSynergy outperformed individual 4C-seq algorithms in leave-one-group-out cross-validation, reaching a mean F1-score of 0.31 and mean ...
Traditional Chinese Medicine Compounds Trigger Cancer Cell Ferroptosis via TP53
Researchers report that ursolic acid and Anhydroicaritin, key components of the traditional formula Fuzheng Yiai, bind and upregulate TP53 to ...
Single-Cell Map Links Endothelial Cell Genes to Lung Cancer Survival
A six-gene endothelial cell signature built from single-cell RNA sequencing data predicts survival outcomes and reveals distinct tumor microenvironment communication ...
Indian environmental mutagenesis conference links pollution, pesticides and DNA damage to human health
The 48th EMSI conference in Jamshedpur featured 141 deliberations linking environmental mutagens, microplastics and pesticides to human health and sustainable ...
Benchmark Finds STAR-Fusion Most Reliable for Detecting Gene Fusions in RNA-seq Data
A new benchmark of eight fusion detection tools shows STAR-Fusion performs most consistently across targeted and simulated bulk RNA-seq data.
