Viral Z-RNA Sensor ZBP1 Emerges as a Switch to Turn Cold Tumors Hot for Immunotherapy
Researchers argue that the innate immune sensor ZBP1, which detects left-handed Z-form nucleic acids and triggers necroptosis, can be pharmacologically ...
Tag: Cancer immunotherapy
Master Switch PRDM1 Steers Natural Killer Cell Maturation and Cancer Defense
A new review details how the transcriptional repressor PRDM1 orchestrates natural killer cell maturation, effector function, and tumor suppression, with ...
Blood-Borne Immune Checkpoint Proteins Linked to Kidney Cancer Risk in New Case-Control Study
A Chinese case-control study finds that soluble immune checkpoint proteins in the blood, particularly CTLA-4, HVEM and CD28, are significantly ...
Immune-cell switch flips the metabolic war between tumors and T cells in immunotherapy-resistant cancers
A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic ...
Innate Immune Memory: How Epigenetic and Metabolic Rewiring Shapes Health and Disease
A new review in the Journal of Molecular Medicine explains how trained immunity, driven by epigenetic and metabolic reprogramming of ...
Immune Cells That Attack the Heart: Multi-Omics Study Reveals Signature of Checkpoint Inhibitor Myocarditis
A multi-omics study identifies ISG15-positive CD8 T cells and a CCL2-CCR2-mediated inflammatory loop as drivers of immune checkpoint inhibitor-induced myocarditis, ...
Hidden RNA Switches: New Tool Reveals lncRNAs That Define Tumor-Fighting T Cells
A new computational framework called SDSGI uncovers subtype-specific long non-coding RNAs in tumor-infiltrating CD8-positive T cells across multiple cancer types, ...
Chromatin Architect Satb1 Reveals a Switch That Disarms Tumor-Protective Immune Cells
New research shows the chromatin organizer Satb1 enables regulatory T cells to promote tumor growth while remaining dispensable for preventing ...
First-in-Human Trial Shows Synthetic Immune Cell Activator IMM60 Is Safe in Advanced Cancer
A first-in-human phase I trial found that the liposomal iNKT cell agonist IMM60, given alone or with pembrolizumab, was well ...
When Tumors Hide Their Flags, Natural Killer Cells May Take Over Against Colorectal Cancer
Two patients with microsatellite-unstable metastatic colorectal cancer and markedly reduced HLA-I expression achieved durable responses to pembrolizumab, suggesting that NK ...
AI Deciphers the Hidden Spatial Rules That Guide Immune Cells Through Tissues
An interpretable machine learning framework called SPACER decodes the gene-level rules that recruit or exclude immune cells in tissues, revealing ...
Lipid nanoparticles reprogram natural killer cells inside the body to fight cancer
MIT researchers have engineered ligand-directed lipid nanoparticles that reprogram natural killer cells into CAR-bearing cancer killers directly inside living animals, ...
High-Dose Vitamin C Reprograms Immune Cells to Boost Pancreatic Cancer Immunotherapy
New research shows that high-dose vitamin C activates the JAK2-STAT1 pathway to drive macrophages toward an anti-tumor M1 state, enhancing ...
RNA Sensor MDA5 Emerges as a Surprising Ally of Tumors Against Immune Attack
New research in Nature Communications shows that the viral RNA sensor MDA5 helps tumors evade immunity, and that disabling it ...
Tumors Are Not Sterile: How Microbes Living Inside Cancers Reshape Immunity and Immunotherapy
A new review in Molecular Cancer argues that microbes living inside tumors dynamically reprogram immunity and can determine whether patients ...
Gut Bacteria and Diet May Explain Why Obesity Sometimes Boosts Cancer Immunotherapy
A McGill University study in Nature finds that certain obesogenic diets improved immunotherapy responses in mice through diet–microbiome synergy, suggesting ...
Immune Cell Engagers Evolve From Simple Bridges to Smart Biomaterial Platforms
A new review charts how immune cell engagers, from bispecific antibodies and aptamers to surface-engineered cells and nanoparticles, are being ...
How a Cellular Stress Switch Helps Tumours Hide From the Immune System
A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could ...
Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
Molecular Scissors: Cysteine Peptidases Emerge as Master Switches of Antitumor Immunity
A new review in iMetaMed reveals how cysteine peptidases such as cathepsins B, S, L, and X control antigen presentation ...
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