Tag: Cancer immunotherapy

New research in Nature Aging shows that accelerated loss of naive CD8+ T cells in middle-aged male mice shrinks lymph ...

Shrinking Lymph Nodes Explain Why Men Lose Cancer-Fighting T Cells Earlier

A Nature Aging study shows that earlier thymic involution and accelerated conversion of naive CD8+ T cells into short-lived virtual ...

Biomaterials That Talk to the Immune System Are Reshaping Immunotherapy

A new review maps how inorganic nanoparticles, polymers, DNA nanostructures, and cell-derived vesicles are being engineered to actively reprogram the ...

Common Antidepressants May Boost Immunotherapy Survival in Cancer Patients, Major Study Finds

A large target trial emulation found that cancer patients on SSRIs while receiving immune checkpoint inhibitors had significantly lower two-year ...

Cancer’s Hidden Proteome: Thousands of Dark Proteins Emerge as Drug Targets

A landmark Perspective in Nature Reviews Cancer argues that the cancer dark proteome — thousands of uncharacterized proteins from non-canonical ...

Tree-Derived Compounds Packaged in Nanoparticles Strip Breast Cancer of Its Immune Shield

Researchers report that Ailanthus excelsa quassinoids delivered in chitosan nanoparticles suppress STAT3-driven PD-L1 transcription and restore T-cell antitumor activity in ...

Platelets Caught Sabotaging Cancer-Killing Immune Cells Through a Single Molecular Handshake

New research shows that activated platelets bind CD8-positive T cells via P-selectin and PSGL-1, directly suppressing their tumor-killing activity and ...

Tiny Vesicles, Big Problem: How Exosomes Drive Cancer Immunotherapy Resistance

A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...

Cancer Immunotherapy Side Effects Differ Sharply Across Racial Groups, Massive Data Analysis Reveals

An analysis of nearly half a million clinical trials and real-world data from over 91,000 patients reveals that immune-related side ...

Sugar Switch on Immune Cells Could Push Macrophages Back Into Cancer-Fighting Mode

Researchers found that blocking the enzyme ST6GAL1 reverses a sugar-linkage switch on macrophages, restoring tumor-fighting behavior and slowing colorectal cancer ...

Why Promising Immune Biomarkers Collapse in the Clinic: New Framework Predicts Failure Before Validation

A new computational framework quantifies why immune biomarkers that perform brilliantly in discovery datasets so often fail in clinical validation, ...

Metabolism Holds the Key to Stronger CAR T Cell Therapies, Review Argues

A Nature Reviews Cancer review argues that metabolism, from CAR design and manufacturing conditions to the patient's diet, is a ...

Electric Pulses Beat Heat and Cold at Turning Dead Tumor Cells Into Cancer Vaccines

A controlled in vitro study shows irreversible electroporation induces stronger dendritic cell activation and T cell proliferation than cryoablation or ...

Iron-Powered Cell Death Emerges as Double-Edged Sword in Cancer’s Microenvironment

A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...

Engineered Macrophages Emerge as a New Frontier in Cell Therapy for Solid Tumors

A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...

SPP1 emerges as a master switch shaping the tumor immune landscape

A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...

Nature’s Immune Boosters: How Natural Adjuvants Could Transform Cancer Therapy