Skeleton’s metabolic aging reshapes osteoporosis research
A new review links age-driven disruptions in bone cell metabolism to osteoporosis and maps emerging therapies targeting NAD+ decline, mitochondrial ...
Tag: AMPK
CD90 Splits Muscle Stem Cells Into Fast-Activating and Dormant States
CD90 divides quiescent muscle stem cells in mouse and human muscle into a fast-activating fraction driven by a CD90-AMPK axis ...
Plant Polyphenols May Steer Muscle Protein Deposition Through mTOR and AMPK
A new review maps how plant polyphenols such as quercetin, curcumin, and resveratrol may regulate muscle protein synthesis and degradation ...
Bone Marrow Hormone MYDGF Eases Fatty Liver Disease in Diabetic Mice
A bone marrow-derived growth factor called MYDGF improved fatty liver disease in diabetic mice by activating a signalling pathway that ...
Citrus Bitterness Compounds May Do More Than Ruin Your Juice
A new review argues that the limonoids responsible for delayed bitterness in citrus juice also show metabolic, cardioprotective, and anti-aging ...
Saikosaponin A Shows Promise for Diabetic Wound Healing in Mouse Study
In a preclinical study, saikosaponin A accelerated wound closure in diabetic mice and was associated with suppressed macrophage pyroptosis and ...
Plant compounds may rewire immune metabolism in heart disease, evidence still thin
A new review maps how plant-derived compounds might modulate immune-cell metabolism in cardiovascular disease, while stressing that most evidence remains ...
Patient-Derived Heart Cells Reveal Susceptibility to Osimertinib-Induced Cardiac Dysfunction
Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking ...
Magnesium Sulfate Shows Neuroprotective Effects in Mouse Model of Postoperative Cognitive Dysfunction
A new experimental study links magnesium sulfate's neuroprotective effects to AMPK/PINK1/Parkin signaling in postoperative cognitive dysfunction.
Plant Triterpenoids Show Promise Against Obesity, But Human Evidence Remains Thin
A Frontiers in Aging review argues that natural triterpenoids such as celastrol, ursolic acid and ginsenosides could complement existing obesity ...
mTORC1 may act as a transition switch in ME/CFS post-exertional malaise
A new review proposes mTORC1 as a transition switch linking mitochondrial dysfunction to post-exertional malaise in ME/CFS, while noting that ...
Smart Hydrogel Delivers CRISPR Gene Editing to Treat Degenerating Spinal Discs in Rats
A pH- and ROS-responsive hydrogel carrying CRISPR-Cas9 silenced the TRPV4 calcium channel in rat discs, restoring autophagic flux and slowing ...
OSBPL3 Drives Colorectal Cancer Growth by Rewiring Cholesterol and Fat Metabolism
A new study reports that the lipid transport protein OSBPL3 promotes colorectal cancer progression through a cholesterol-linked signaling loop involving ...
Seaweed fiber fucoidan reshapes gut microbiota and protects mice from fatty liver disease
A 14-week mouse study found that fucoidan, a sulfated polysaccharide from brown seaweed, attenuated high-fat-diet-induced fatty liver disease in association ...
Experimental AMPK activator traps esophageal cancer cells in S phase, priming them for chemotherapy
A laboratory study reports that the AMPK activator AICAR selectively arrests esophageal squamous cell carcinoma cells in S phase through ...
Exercise-linked muscle peptide reduces fatty liver through ACE2 in mice
A study in diabetic mice with fatty liver found that exercise-linked muscle peptide MOTS-c reduced steatosis through an AMPK–ACE2 pathway.
TIMD4-targeted nanoparticles reduce colitis inflammation in mice
A macrophage-targeted TIMD4 peptide nanoparticle reduced inflammation and monocyte recruitment in a mouse colitis model without establishing clinical benefit in ...
Mouse study links spinal Hsp90 inhibition to enhanced morphine pain relief through DUSP15 in CGRP neurons
In mice, spinal Hsp90 inhibition enhanced morphine pain relief, and DUSP15 knockdown in CGRP neurons reversed that effect.
Post-remission muscle loss in rheumatoid arthritis improved by dipyridamole in mice
In a mouse model of rheumatoid arthritis, dipyridamole improved persistent muscle loss and dysfunction after joint inflammation subsided, alongside restored ...
NUAK1 and NUAK2 drive colorectal cancer metabolic changes in cells
Human tissue associations and cell experiments link NUAK1 and NUAK2 to colorectal cancer growth, migration and metabolic reprogramming through AMPK ...
POPULAR NEWS
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Two C3 Gene Variants Reveal Functional Independence Between Extracellular and Intracellular Forms of Complement C3
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Nearly Half of Stroke Patients in Africa and Asia Show Low HDL Cholesterol
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German heat-health plans rarely evaluated due to political and structural barriers, study finds
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Carb Quality Beats Glycemic Index in Sperm DNA Study