Optical Changes in Diabetic Adipose Tissue Track Early Glycation and Hydration
A multimodal study reveals that early type 1 diabetes alters adipose tissue optical properties by modulating collagen and phospholipid hydration ...
Tag: adipose tissue
UC Riverside Finds Sex-Specific Immune Roles in Fat
UC Riverside scientists found that sex-specific immune cell behavior in fat tissue influences how males and females respond to obesity.
Depletion of MKP-2 Alters Adipose Lipids and Extends Lifespan in Mice
Researchers discovered that genetic deletion of the phosphatase MKP-2 reduces cellular senescence, remodels adipose lipid composition, and extends median lifespan ...
GUSB-Enriched Sympathetic Neurons Promote Adipose Thermogenesis in Male Mice
A study in male mice reveals that GUSB-enriched sympathetic neurons remodel the extracellular matrix to promote thermogenic recruitment and counter ...
RNA-processing enzyme Star-PAP stabilizes insulin receptor mRNA and guards fat tissue
A rare Star-PAP variant found in lean individuals led researchers to discover that this polyadenylation enzyme stabilizes insulin receptor mRNA ...
DNA Methylation Links Failing Fat Cell Formation to Obesity and Diabetes
A new review describes how aberrant DNA methylation and premature senescence of fat cell precursors drive adipose tissue dysfunction in ...
Caloric Restriction Beats Time-Restricted Feeding on Metabolism in Obese Rats, but TRF Shifts Behavior
In obese rats fed a high-sugar diet, caloric restriction produced stronger metabolic improvements than time-restricted feeding, which instead showed distinct ...
How metabolism may reshape DNA methylation across the cardiovascular–kidney–metabolic continuum
A new review synthesizes evidence that metabolic stress may shape DNA methylation through methyl-donor availability, impaired demethylation, and chromatin changes ...
Electrical and Optical Properties Distinguish Adipose Tissue Depots and Offer a Promising Route to Monitoring Beiging
Researchers at the University of Oslo report that the passive electrical and optical properties of adipose tissue can distinguish between ...
Testosterone and obesity interact differently in men and women, review finds
A new review details how testosterone and obesity reinforce each other in opposite directions in men and women.
New mouse tool targets microvascular endothelial cells in muscle and fat
Scientists have created a CTRP9-CreERT2 knock-in mouse line whose tamoxifen-inducible reporter selectively labels microvascular endothelial cells in heart, skeletal muscle, ...
Multi-omics study points to glycolytic genes as suggestive links to insulin resistance in obesity
A multi-omics Mendelian randomization study identifies HKDC1 and ITGAM as suggestive glycolytic candidates genetically associated with insulin resistance in metabolically ...
Scientists pinpoint THBS1 as a driver of fat tissue scarring in obesity and diabetes
A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...
New Mouse Model Tracks Calorie-Burning Brown Fat With Fewer Brain Off-Target Effects
Researchers at LSU's Pennington Biomedical Research Center have characterized a UCP1-IRES-Cre knock-in mouse that targets brown and beige fat far ...
Mouse study links endothelial FoxO1 to female vascular resilience
A mouse study found that endothelial FoxO1 supports capillary remodeling, mitochondrial integrity and metabolic health in females while producing opposite ...
Renin–Angiotensin System Activation Drives Early Cardiorenal Dysfunction in Normotensive Prediabetes
In normotensive, non-obese prediabetic male rats, increased ACE in adipose tissue was linked to early autonomic, renal vascular, and kidney ...
Adipose markers hint at neurological recovery after in-hospital cardiac arrest
Two exploratory cohorts link regional fat thickness and circulating adipokines with neurological outcomes after in-hospital cardiac arrest, but neither establishes ...
Canine study finds stromal vascular fraction and xanthosine independently improve surgical wound healing
A randomized study in 24 dogs found that stromal vascular fraction and xanthosine each improved surgical wound-healing measures, with the ...
Gentle support-bath bioprinting keeps mature human fat cells alive in 3D
Researchers at the University of Stuttgart have developed a support-bath bioprinting method that embeds fragile mature human fat cells into ...
Bariatric Surgery Rewrites the Genetic Script of Fat Tissue, but a Stubborn Molecular Memory Remains
A detailed transcriptomic study of subcutaneous and visceral fat in women with severe obesity reveals that bariatric surgery partially restores ...
