• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Monday, March 1, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Study reveals a new potential mechanism underlying loss of muscle mass during menopause

Bioengineer by Bioengineer
February 18, 2021
in Health
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

A new study conducted in collaboration between the universities of MinnA new study reveals that estrogen deficiency alters the microRNA signalling in skeletal muscle

IMAGE

Credit: University of Jyväskylä.

Menopause is associated with several physiological changes, including loss of skeletal muscle mass. However, the mechanisms underlying muscle wasting are not clear. A new study conducted in collaboration between the universities of Minnesota (USA) and Jyväskylä (Finland) reveals that estrogen deficiency alters the microRNA signalling in skeletal muscle, which may activate signalling cascades leading to loss of muscle mass.

Menopause leads to an estrogen deficiency that is associated with decreases in skeletal muscle mass and strength. This is likely due to changes in both muscle function and the size of muscle cells commonly referred to as fibers.

“The mechanistic role of estrogen in the loss of muscle mass had not been established. In our study, we focused on signaling cascades in skeletal muscle that eventually lead to cell death,” explains Academy of Finland postdoctoral researcher Sira Karvinen from the Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.

One possible signaling route leading to cell death involves microRNA molecules. MicroRNA molecules regulate gene expression by inhibiting targeted protein synthesis. To date, several microRNAs have been found to regulate key steps in cell death pathways and hence may regulate the number of muscle cells.

“In our previous studies we have established estrogen responsive microRNAs in both blood and muscle of menopausal women,” says the principal investigator, Academy research fellow Eija Laakkonen. “Now we investigated this observation in more detail by utilizing an animal model of low and high systemic estrogen levels provided by Professor Dawn Lowe’s group working at the University of Minnesota.”

The study revealed that estrogen deficiency downregulated several microRNAs linked to cell death pathways in muscle. This observation was associated with upregulation of cell death proteins.

“Thus, estrogen responsive micro-RNAs may share a mechanistic role in muscle wasting during menopause,” says Karvinen. “One preventative strategy recommended is for women to engage in resistance training especially at middle-age to aid in maintaining muscle mass and power.”

###

The study was carried out in collaboration between the universities of Minnesota (USA) and Jyväskylä (Finland) and was funded by National Institutes of Health (NIH, USA) and the Academy of Finland.

Media Contact
Sira Karvinen
[email protected]

Original Source

https://www.jyu.fi/en/current/archive/2021/02/study-reveals-a-new-potential-mechanism-underlying-loss-of-muscle-mass-during-menopause

Related Journal Article

http://dx.doi.org/10.1016/j.exger.2021.111267

Tags: BehaviorDemographyExerciseGerontologyGynecologyMedicine/HealthMusculaturePublic HealthSports/Recreation
Share12Tweet7Share2ShareShareShare1

Related Posts

IMAGE

The role of human behavior is critical for advancing comfort knowledge

March 1, 2021
IMAGE

Pre-schoolers frequently using tablet or mobile can’t see the forest for the trees

March 1, 2021

Genetic study uncovers hidden pieces of?eye disease?puzzle?

March 1, 2021

Behavior of wild capuchin monkeys can be identified by marks left on their tools

March 1, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    650 shares
    Share 260 Tweet 163
  • People living with HIV face premature heart disease and barriers to care

    82 shares
    Share 33 Tweet 21
  • Global analysis suggests COVID-19 is seasonal

    38 shares
    Share 15 Tweet 10
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Climate ChangePublic HealthChemistry/Physics/Materials SciencescancerInfectious/Emerging DiseasesTechnology/Engineering/Computer ScienceBiologyCell BiologyMaterialsMedicine/HealthGeneticsEcology/Environment

Recent Posts

  • Scientists describe ‘hidden biodiversity crisis’ as variation within species is lost
  • Socioeconomic status plays a major role in cognitive outcomes
  • Natural product isolated from sea sponge tested against cancer cells
  • Oncotarget: Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In