• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, February 25, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Strange colon discovery explains racial disparities in colorectal cancer

Bioengineer by Bioengineer
January 21, 2021
in Health
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

One side of the colon ages faster than the other, scientists reveal

IMAGE

Credit: UVA Health

The colons of African-Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer – the cancer that killed beloved “Black Panther” star Chadwick Boseman at only 43.

Scientists led by UVA Health’s Li Li, MD, PhD; Graham Casey, PhD; and Matt Devall, PhD, of the Center for Public Health Genomics, found that one side of the colon ages biologically faster than the other in both African-Americans and people of European descent. In African-Americans, however, the right side ages significantly faster, explaining why African-Americans are more likely to develop cancerous lesions on the right side and why they are more likely to suffer colorectal cancer at a younger age, the researchers say.

“Our discovery provides novel insight of the mechanistic underpinning for the observed racial disparities in age-of-onset and anatomical distribution of colon neoplasia,” said Li, the leader of the Cancer Control and Population Health program at UVA Cancer Center. “Side-specific biological aging of the colon might emerge as a novel biomarker to guide the development of personalized prevention and intervention strategies.”

Colons Old Beyond Their Years

African-Americans are disproportionately affected by colorectal cancer. The American Cancer Society reports that African-Americans are 20% more likely to develop colorectal cancer and 40% more likely to die from it. Overall colorectal cancer rates have declined in America in recent years, but African-Americans have not seen the same decreases as people of European descent. And even as the overall rates have dropped, the rate among younger people has gone up.

While doctors have long appreciated these disparities, they haven’t really understood the causes. The new study helps answer those questions. It’s the first to show that the right and left side of the colon actually age differently.

The researchers made this determination by looking at the DNA in colon tissue, and the “epigenetic” changes that come with age. These epigenetic changes are not alterations to the genes but changes that affect how the genes work and how well they can do their jobs.

The scientists found that the right side of the colon in most African-Americans had suffered a unique pattern of “hypermethylation,” affecting gene expression. It was, in essence, like the right side was old beyond its years. This, the researchers believe, could contribute to African-Americans’ increased cancer risk and could explain why they are more likely to develop cancerous lesions on the right side.

The research could also explain why younger people of European descent are more likely to develop lesions on the left side – the side that tends to age faster in that group.

“These findings highlight the importance of colon sidedness to biology of colorectal cancer,” Casey said. “The fact that the colon biology of people of African and European ancestry differ further highlights the critical importance of more research involving participation of people of African descent.”

Li and his team say further investigation of what they have found could lead to better ways to treat and prevent colorectal cancers.

“We are working to validate our discovery in independent patient cohorts,” Li said. “Our discovery is a step forward in our effort to prevent colorectal cancer and reduce racial disparities in this deadly disease.”

###

Findings Published

The researchers have published their findings in the Journal of the National Cancer Institute. The research team consisted of Matthew Devall, Xiangqing Sun, Fangcheng Yuan, Gregory S. Cooper, Joseph Willis, Daniel J. Weisenberger, Graham Casey and Li Li.

The work was supported by the National Cancer Institute Cancer Disparities SPORE Planning Grant (P20 CA233216), Case Comprehensive Cancer Center GI SPORE (P50 CA150964), National Cancer Institute (CA143237) and a pilot grant from the UVA Cancer Center (P30CA044579).

To keep up with the latest medical research news from UVA, subscribe to the Making of Medicine blog at http://makingofmedicine.virginia.edu.

Media Contact
Josh Barney
[email protected]

Original Source

https://newsroom.uvahealth.com/2021/01/21/strange-colon-discovery-explains-racial-disparities-in-colorectal-cancer/

Related Journal Article

http://dx.doi.org/10.1093/jnci/djaa206

Tags: AgingBiologycancerCarcinogensDeath/DyingGastroenterologyInternal MedicineMedicine/HealthMortality/LongevityPublic Health
Share12Tweet8Share2ShareShareShare2

Related Posts

IMAGE

New radiology research shows promising results for focused ultrasound treatment of Alzheimer’s

February 25, 2021
IMAGE

New ONC, NLM funding supports data exchange and response to COVID-19 pandemic

February 25, 2021

Salk Professors Satchin Panda and Tatyana Sharpee honored with endowed chairs

February 25, 2021

New treatment location challenges thoughts on addiction

February 25, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    637 shares
    Share 255 Tweet 159
  • People living with HIV face premature heart disease and barriers to care

    81 shares
    Share 32 Tweet 20
  • Global analysis suggests COVID-19 is seasonal

    37 shares
    Share 15 Tweet 9
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

MaterialsInfectious/Emerging DiseasesGeneticsPublic HealthClimate ChangeChemistry/Physics/Materials SciencesCell BiologyEcology/EnvironmentTechnology/Engineering/Computer SciencecancerBiologyMedicine/Health

Recent Posts

  • NTU scientists develop laser system that generates random numbers at ultrafast speeds
  • Scientists probe electronic angular momentum to a chemical reaction for the first time
  • Zebra finches choose nest materials based on past experience, new research shows
  • New radiology research shows promising results for focused ultrasound treatment of Alzheimer’s
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In