• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Saturday, June 21, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Repeated pregnancy loss may be tied to the olfactory system

Bioengineer by Bioengineer
September 29, 2020
in Health
Reading Time: 4 mins read
0
ADVERTISEMENT
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Understanding the connection could lead to a new search for the causes of unexplained spontaneous miscarriage

IMAGE

Credit: Weizmann Institute of Science

The odors we give off are a sort of body language – one that may affect our relationships more than we realize. New research from the lab of Prof. Noam Sobel at the Weizmann Institute of Science suggests this “chemical communication” may extend to human reproduction as well. The study, which was published today in eLife, found that women who suffer from a condition known as unexplained repeated pregnancy loss (uRPL) process messages concerning male body odor in a different way than other women. These findings may point to new directions in the search for causes and prevention of this poorly understood disorder.

Sobel and his team in the Institute’s Neurobiology Department thought that some cases of uRPL could be related to a human variation on the Bruce effect, named after its discoverer Hilda Bruce, who found in 1959 that when pregnant mice are exposed to the body-odor of a a male that did not father the pregnancy, they will almost always abort. Why this occurs is not fully understood, but the common rational is that the female “chooses” to abort because the chemical message is that a new “more fit” male is in town.

Could a similar effect occur in women? A remarkable estimated 50% of all human conceptions and some 15% of documented human pregnancies, end in spontaneous miscarriage. Ethical considerations obviously prevented the researchers from repeating the Bruce experiments in humans; But the team instead sought circumstantial evidence.

For the Bruce effect to occur in mice, the female must remember the body-odor of the fathering male. To test for this in humans, the researchers presented participants with three odorants: one extracted from a t-shirt worn by their spouse, and two from t-shirts worn by non-spouse men. They found that women with uRPL were able to identify their spouse by smell, while the control women could not. When retested with ordinary odorants to see if those with uRPL simply had a better sense of smell overall, they tested only marginally better. The ability of uRPL women to identify their spouse by smell was remarkable: In another part of the experiment, in which the women did not know what odors they would be smelling, “several of these women said ‘oh, my husband’s in here’,” says research student Reut Weissgross, who co-lead the study. This never happened once with the control women.

Further testing suggested that these women are not just better at picking out the smell of their spouse, they may experience men’s body-odor in a different way altogether. When asked to rate men’s body-odors on various scales, including ranking them by standard scales for pleasantness and intensity, but also by such factors as fertility or sex appeal, the uRPL-affected women were unique in the way they described and graded the smells, and significantly different from control women in their answers.

In the final phase of the research, the experimenters used both structural and functional brain imaging to study these women. The structural imaging revealed that women with uRPL have smaller olfactory bulbs; these are the initial brain-relay for smell. Using functional imaging, they found an increased response to men’s body-odors in the hypothalamus of women with uRPL. The hypothalamus plays a key role in the Bruce effect in mice, and it is a brain region that participates, among other things, in coordinating pregnancy and overall hormonal regulation.

“It seems these losses of pregnancy may be ‘unexplained’ because physicians are looking for problems in the uterus, when they should also be looking in the brain, and particularly the olfactory brain” says Weissgross. Sobel cautions: “Correlation is not causation, so our findings do not prove in any way that the olfactory system, or body-odors, cause miscarriage. But our findings do point to a novel and potentially important direction for research in this poorly managed condition.”

###

The study was co-lead by Dr. Liron Rozenkrantz, Reut Weissgross, and Dr. Tali Weiss, all in Sobel’s lab, and it was conducted in collaboration with Prof. Howard Carp, head of the uRPL clinic at Sheba, Tel Hashomer Medical Center.

Prof. Noam Sobel is Head of the Azrieli National Institute for Human Brain Imaging and Research; his research is also supported by the Norman and Helen Asher Center for Human Brain Imaging; the Nadia Jaglom Laboratory for the Research in the Neurobiology of Olfaction; the Rob and Cheryl McEwen Fund for Brain Research; and Sonia T. Marschak. Prof. Sobel is the incumbent of the Sara and Michael Sela Professorial Chair of Neurobiology.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world’s top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

Media Contact
Yael Edelman
[email protected]

Original Source

https://wis-wander.weizmann.ac.il/life-sciences/repeated-pregnancy-loss-may-be-tied-olfactory-system

Tags: FertilityMedicine/HealthneurobiologyOlfactory/Taste
Share12Tweet8Share2ShareShareShare2

Related Posts

blank

Gasdermin E Drives Pyroptosis Resistance in Glioblastoma

June 21, 2025
blank

AI Diagnoses Vocal Cord Paralysis Severity

June 21, 2025

Humeral Rotation Impacts Rotator Cuff Mechanics

June 21, 2025

Racial Disparities Impact Neonatal Hypoxic-Ischemic Outcomes

June 21, 2025
Please login to join discussion

POPULAR NEWS

  • Green brake lights in the front could reduce accidents

    Study from TU Graz Reveals Front Brake Lights Could Drastically Diminish Road Accident Rates

    161 shares
    Share 64 Tweet 40
  • New Study Uncovers Unexpected Side Effects of High-Dose Radiation Therapy

    76 shares
    Share 30 Tweet 19
  • Pancreatic Cancer Vaccines Eradicate Disease in Preclinical Studies

    71 shares
    Share 28 Tweet 18
  • How Scientists Unraveled the Mystery Behind the Gigantic Size of Extinct Ground Sloths—and What Led to Their Demise

    65 shares
    Share 26 Tweet 16

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Gasdermin E Drives Pyroptosis Resistance in Glioblastoma

AI Diagnoses Vocal Cord Paralysis Severity

Humeral Rotation Impacts Rotator Cuff Mechanics

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.