• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Friday, May 20, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Ready, set, go – how stem cells synchronise to repair the spinal cord in axolotls

Bioengineer by Bioengineer
June 22, 2021
in Biology
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: L. Otsuki/IMP

The spinal cord is an important component of our central nervous system: it connects the brain with the rest of the body and plays a crucial part in coordinating our sensations with our actions. Falls, violence, disease – various forms of trauma can cause irreversible damage to the spinal cord, leading to paralysis, sometimes even death.

Although many vertebrates, including humans, are unable to recover from a spinal cord injury, some animals stand out. For instance, the axolotl (Ambystoma mexicanum), a salamander from Mexico, has the remarkable ability to regenerate its spinal cord after an injury. When an axolotl’s tail is amputated, neural stem cells residing in the spinal cord are recruited to the injury to rebuild the tail. So far, scientists could only detect this activity a few days after the process had started.

“Four days after amputation, stem cells within about one millimetre of the injury divide three times as fast as the normal rate to regenerate the spinal cord and replace lost neurons,” explains Emanuel Cura Costa, co-first author of the study. “What the stem cells are doing in the first four days after injury was the real mystery.”

To understand what happens in the first moments of spinal cord regeneration, researchers at CONICET, IMP, and TU Dresden teamed up to recreate the process in a mathematical model and test its predictions in axolotl tissue with the latest imaging technologies. Their findings, published in eLife, show that neural stem cells accelerate their cell cycles in a highly synchronised manner, with the activation spreading along the spinal cord.

Regenerating in sync: cells follow the tempo

In the uninjured spinal cord, cells multiply asynchronously: some are actively replicating their DNA before splitting into two cells to sustain growth, while some are simply resting.

The scientists’ model predicted that this could change dramatically upon injury: most cells in the vicinity of the injury would jump to a specific stage of the cell cycle to synchronise and proliferate in unison.

“We developed a tool to track individual cells in the growing spinal cord of axolotls. Different colours label resting and active cells, which allow us to see how far and how fast cell proliferation happens with a microscope,” says Leo Otsuki, postdoc in the lab of Elly Tanaka at the IMP and co-first author of this study. “We were very excited to see the match between the theoretical predictions and the experimental results.”

The way cells multiply in chorus in the regenerating spinal cord is exceptional in animals. How can cells coordinate their efforts over almost one millimetre – 50 times the size of a single cell?

A mystery signal orchestrating regeneration

“Our model made us realise there had to be one or more signals that spread through the tissue from the injury, like a wave, for the area of proliferating cells to expand,” explains Osvaldo Chara, career researcher at CONICET, group leader of SysBio at the Institute of Physics of Liquids and Biological Systems (IFLySIB) and guest professor at Center for Information Services and High Performance Computing (ZIH), Technische Universität Dresden. “This signal might act like a messenger and instruct stem cells to proliferate.”

The researchers suspect that this mystery messenger helps reprogram stem cells to divide rapidly and regrow amputated tissue. Their work pinpoints this signal in space and time, and paves the way to characterise it further.

“Combining mathematical models with our expertise in tissue imaging was key to understanding how the spinal cord starts regenerating,” says Elly Tanaka, senior scientist at the IMP. “The next step is to identify the molecules that promote regeneration of the spinal cord – that could have tremendous therapeutic potential for patients with spinal injuries.”

###

Original publication

Cura Costa, E., Otsuki, L., Rodrigo Albors, A., Tanaka, E. M., Chara, O.: “Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration”. eLife, 8 June 2021. DOI: https://doi.org/10.7554/eLife.55665.

The image of this press release and further illustrations and videos can be downloaded from the IMP website at http://www.imp.ac.at/supplements.

About the IMP

The Research Institute of Molecular Pathology (IMP) in Vienna is a basic life science research institute largely sponsored by Boehringer Ingelheim. With over 200 scientists from 40 countries, the IMP is committed to scientific discovery of fundamental molecular and cellular mechanisms underlying complex biological phenomena. The IMP is part of the Vienna BioCenter, one of Europe’s most dynamic life science hubs with 2,000 employees from 70 countries in four research institutes, three universities and almost 40 biotech companies.

http://www.imp.ac.at, http://www.viennabiocenter.org

About CONICET

CONICET is the main agency that fosters science and technology in Argentina. Currently, the Council has more than 10,000 researchers, 11,000 doctoral and postdoctoral fellows, 2,600 technicians and professional support staff, and 1,500 administrative employees. They all operate across the whole country in 15 Scientific and Technological Centers (CCT), 11 research and transference centers (CIT), a Multidisciplinary Research Center and more than 280 Institutes and exclusive CONICET Centers under the scope of national universities and other institutions.

https://www.conicet.gov.ar/

About the ZIH at TU Dresden

TU Dresden is one of the largest technical universities in Germany with more than 31,000 students. Since 2012, it is one of the eleven Excellence Initiative universities in Germany. Bioengineering is among its five research priority areas. ZIH is the university IT center and the High Performance Computing (HPC) competence center for TU Dresden and the state of Saxony. Since 2021, ZIH is one of eight national centers for HPC and thus offers its services to academic users from all over Germany. An important aspect of the research work at ZIH is the development of algorithms for modeling the biological processes that occur in cells. Its department of Innovative Methods of the Computing is targeted at the development of innovative mathematical models and simulation tools to detect organizational principles of selected biological systems.

https://tu-dresden.de/zih/

Media Contact
Jacqueline Papperitz
[email protected]

Related Journal Article

http://dx.doi.org/10.7554/eLife.55665

Tags: BiologyCell Biology
Share12Tweet8Share2ShareShareShare2

Related Posts

Blood python in Kaeng Krachan National Park in Thailand

Snake trade in Indonesia is not sustainable enough — but it could be

May 20, 2022
Team finds link between dietary cholesterol and influenza severity

Dietary cholesterol worsens inflammation, sickness in mice with influenza

May 19, 2022

Bird flu is driven by ecologically diverse species, with wild ducks, gulls, geese, and poultry playing a role in global spread

May 19, 2022

Avian influenza: How it’s spreading and what to know about this outbreak

May 19, 2022
Please login to join discussion

POPULAR NEWS

  • Weybourne Atmospheric Observatory

    Breakthrough in estimating fossil fuel CO2 emissions

    46 shares
    Share 18 Tweet 12
  • Hidden benefit: Facemasks may reduce severity of COVID-19 and pressure on health systems, researchers find

    44 shares
    Share 18 Tweet 11
  • Discovery of the one-way superconductor, thought to be impossible

    43 shares
    Share 17 Tweet 11
  • Sweet discovery could drive down inflammation, cancers and viruses

    43 shares
    Share 17 Tweet 11

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

VirusUniversity of WashingtonUrogenital SystemVirologyVehiclesWeaponryUrbanizationVaccinesVaccineWeather/StormsZoology/Veterinary ScienceViolence/Criminals

Recent Posts

  • Snake trade in Indonesia is not sustainable enough — but it could be
  • ‘Moth motorways’ could help resist climate change impact
  • Satellites and drones can help save pollinators
  • What the new Jurassic Park movie gets wrong: Aerodynamic analysis causes a rethink of the biggest pterosaur.
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....