• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, June 20, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

People at high genetic risk for colorectal cancer benefit more from lifestyle changes

Bioengineer by Bioengineer
May 14, 2021
in Health
Reading Time: 2 mins read
0
ADVERTISEMENT
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Vanderbilt University Medical Center

People with a high polygenic risk score for colorectal cancer could benefit more at preventing the disease by leading healthy lifestyles than those at lower genetic risk, according to a study by Vanderbilt researchers published in the April issue of The American Journal of Clinical Nutrition.

Analyzing data from participants in the UK Biobank, the researchers estimated that maintaining a healthy lifestyle was associated with a nearly 40% reduction in colorectal cancer risk among those with a high genetic risk of developing the disease. The percentage dropped to only about 25% among people at a low genetic risk for this cancer. People with a high genetic risk and an unhealthy lifestyle were more than three times as likely to be diagnosed with colorectal cancer than those with a low genetic risk and a healthy lifestyle.

“Results from this study could be useful to design personalized prevention strategies for colorectal cancer prevention,” said Wei Zheng, MD, PhD, MPH, Anne Potter Wilson Professor of Medicine and associate director for Population Sciences Research at Vanderbilt-Ingram Cancer Center (VICC).

In the analysis, lifestyle scores of unhealthy, intermediate and healthy were determined according to waist-to-hip ratio, physical activity, sedentary time, processed and red meat intake, vegetable and fruit intake, alcohol consumption and tobacco use. Polygenic risk scores are used to measure genetic susceptibility to colorectal cancer. Vanderbilt researchers constructed polygenic risk scores using genetic variants associated with colorectal cancer risk identified in recent large genetic studies including more than 120,000 study participants. They also constructed polygenetic risk scores for several other common cancers in research that was published last year in JNCI Cancer Spectrum.

The recently published study in The American Journal of Clinical Nutrition is one of the few that quantifies potential interactions of overall lifestyle with genetic susceptibility to colorectal cancer.

###

The study’s other authors are Jungyoon Choi, M.D, Guochong Jia, MPH, Wanqing Wen, MD, MPH, research associate professor of Medicine and Xiao-Ou Shu, MD, PhD, Ingram Professor of Cancer Research.

The research was supported in part by funds provided by the Anne Potter Wilson chair endowment at Vanderbilt University and a research grant from the National Cancer Institute.

Media Contact
Tommy Wilemon
[email protected]

Related Journal Article

http://dx.doi.org/10.1093/ajcn/nqaa404

Tags: BehaviorcancerDiet/Body WeightExerciseMedicine/Health
Share12Tweet8Share2ShareShareShare2

Related Posts

blank

Organoid Model Reveals Residual Colorectal Cancer Stem Cells

June 20, 2025
Targeting Cell Death to Combat Early Liver Cancer

Targeting Cell Death to Combat Early Liver Cancer

June 19, 2025

Butyrate Restores Sleep in Parkinson’s Mice via BDNF

June 19, 2025

Practical Hours-Based Scheduling in Neonatology Care

June 19, 2025
Please login to join discussion

POPULAR NEWS

  • Green brake lights in the front could reduce accidents

    Study from TU Graz Reveals Front Brake Lights Could Drastically Diminish Road Accident Rates

    161 shares
    Share 64 Tweet 40
  • New Study Uncovers Unexpected Side Effects of High-Dose Radiation Therapy

    76 shares
    Share 30 Tweet 19
  • Pancreatic Cancer Vaccines Eradicate Disease in Preclinical Studies

    71 shares
    Share 28 Tweet 18
  • How Scientists Unraveled the Mystery Behind the Gigantic Size of Extinct Ground Sloths—and What Led to Their Demise

    65 shares
    Share 26 Tweet 16

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Organoid Model Reveals Residual Colorectal Cancer Stem Cells

Terahertz Spectroscopy Maps Buried PN Junction Depths

Revolutionizing Rehabilitation: Virtual Reality Offers New Hope for Stroke Survivors to Recover Movement

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.