• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Monday, August 4, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Oncotarget: Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells

Bioengineer by Bioengineer
June 28, 2021
in Health
Reading Time: 4 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Support recently reported findings of clinical benefit when relacorilant is added to paclitaxel-containing therapy in patients with ovarian and pancreatic cancers and provide a new rationale for combining relacorilant with additional cytotoxic agents

IMAGE

Credit: Correspondence to – Andrew E. Greenstein – [email protected]

Oncotarget published “Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells” which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

In the MIA PaCa-2 cell line, paclitaxel-driven apoptosis was blunted by cortisol and restored by relacorilant.

A screen to identify optimal combination partners for relacorilant showed that microtubule-targeted agents consistently benefited from combination with relacorilant.

These findings were confirmed in xenograft models, including MIA PaCa-2, HeLa, and a cholangiocarcinoma patient-derived xenograft. In vivo, tumor-cell apoptosis was increased when relacorilant was added to paclitaxel in multiple models.

These observations support recently reported findings of clinical benefit when relacorilant is added to paclitaxel-containing therapy in patients with ovarian and pancreatic cancers and provide a new rationale for combining relacorilant with additional cytotoxic agents.

Support recently reported findings of clinical benefit when relacorilant is added to paclitaxel-containing therapy in patients with ovarian and pancreatic cancers and provide a new rationale for combining relacorilant with additional cytotoxic agents.

Dr. Andrew E. Greenstein from Corcept Therapeutics said, “Drug resistance, whether primary or acquired, is a major impediment to cancer therapy.“

GR agonism could contribute to tumor cell biology even in patients with normal cortisol levels.

GR agonists, including cortisol, have demonstrated pro-apoptotic effects in hematological malignancies, cytostatic effects on sarcoma-derived cell lines, and anti-apoptotic effects in carcinoma cell lines.

Unlike the non-specific steroidal GR antagonist mifepristone, relacorilant does not exhibit partial agonist activity toward human or mouse GR.

Mifepristone and relacorilant are both competitive antagonists of the GR and are best studied in the context of physiologically relevant cortisol concentrations.

In a phase 2 study in patients with Cushing syndrome, relacorilant demonstrated the ability to reverse the effects of excess cortisol on hypertension and insulin resistance, and it is currently being studied in two phase 3 trials in patients with endogenous Cushing syndrome, GRACE and GRADIENT.

The Greenstein Research Team concluded in their Oncotarget Research Output that the initial in vitro observations suggested that an increase in apoptosis, rather than a decrease in proliferation rate, was achieved when relacorilant was added to a cytotoxic therapy.

To determine if this was recapitulated in vivo, apoptosis markers were assessed in relacorilant-treated xenografts.

The CC6279 cholangiocarcinoma model was assessed because the relacorilant effect size was greatest. Cleaved caspase 3 activity was qualitatively and quantitatively elevated in mice treated with relacorilant paclitaxel compared to paclitaxel alone, while no difference was observed for CK18 and Ki67.

Consistent with the initial in vitro observation, relacorilant promoted tumor cell apoptosis in xenograft models.

###

DOI – https://doi.org/10.18632/oncotarget.27989

Full text – https://www.oncotarget.com/article/27989/text/

Correspondence to – Andrew E. Greenstein – [email protected]

Keywords –
glucocorticoid,
tumors,
apoptosis,
chemotherapy,
drug resistance

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud – https://soundcloud.com/oncotarget
Facebook – https://www.facebook.com/Oncotarget/
Twitter – https://twitter.com/oncotarget
LinkedIn – https://www.linkedin.com/company/oncotarget
Pinterest – https://www.pinterest.com/oncotarget/
Reddit – https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
RYAN JAMES JESSUP
[email protected]

Original Source

https://www.oncotarget.com/news/pr/glucocorticoid-receptor-antagonism-promotes-apoptosis-in-solid-tumor-cells/

Related Journal Article

http://dx.doi.org/10.18632/oncotarget.27989

Tags: BiologyBusiness/EconomicscancerCarcinogensEducationMedicine/HealthPolicy/Ethics
Share12Tweet8Share2ShareShareShare2

Related Posts

August APA Journals Highlight Breakthroughs in Psychiatric Genetics, Telehealth Prescribing, Mental Health Advocacy, and Beyond

August APA Journals Highlight Breakthroughs in Psychiatric Genetics, Telehealth Prescribing, Mental Health Advocacy, and Beyond

August 4, 2025
IMRT vs. VMAT: Impact on Cervical Cancer Survival

IMRT vs. VMAT: Impact on Cervical Cancer Survival

August 4, 2025

Assessing Glucagon-Like Peptide-1 Receptor Agonist Eligibility in US Adolescents and Young Adults

August 4, 2025

Lactate Drives Immune Hotspots; SLC5A12 Inhibition Resolves

August 4, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Neuropsychiatric Risks Linked to COVID-19 Revealed

    65 shares
    Share 26 Tweet 16
  • Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    61 shares
    Share 24 Tweet 15
  • Predicting Colorectal Cancer Using Lifestyle Factors

    46 shares
    Share 18 Tweet 12
  • Dr. Miriam Merad Honored with French Knighthood for Groundbreaking Contributions to Science and Medicine

    46 shares
    Share 18 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Multimodal Dataset Advances Precision Oncology in Head, Neck

Advanced Crop Monitoring System Integrating IoT and AI Unveiled at ASABE

August APA Journals Highlight Breakthroughs in Psychiatric Genetics, Telehealth Prescribing, Mental Health Advocacy, and Beyond

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.