• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, January 21, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

New types of blood cancer discovered in children

Bioengineer by Bioengineer
June 7, 2016
in Cancer
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Through a detailed study of leukaemia cells from more than 200 children, a research group at Lund University in Sweden has discovered two new types of childhood leukaemia. Using next-generation sequencing technology (NGS), the researchers were able to study the genome of cancer cells, which is how they discovered the new types of cancer.

Acute lymphoblastic leukaemia is a rare disease, but the most common form of cancer in children. Today the treatment is very successful, but requires heavy interventions at the risk of causing many side effects. There is therefore a need to distinguish between different types of acute lymphoblastic leukaemia, in order to adapt the treatment according to the severity of each case, and to detect possible relapse.

“Like all types of cancer, childhood leukaemia is caused by genetic mutations in normal cells, which are then transformed into cancer cells. Finding the critical mutations in the diseased cells is an important condition for understanding the mechanisms of the disease and ultimately discovering new therapies”, explains Thoas Fioretos, professor and senior consultant at the Division of Clinical Genetics, and Principal investigator of the project

Through the relatively new next-generation sequencing method, the researchers were able to examine the changes that occur in cancer cells in greater detail, which is how they discovered the two new types of childhood leukaemia.

“One type occurs when a gene called DUX4, which is normally inactive in blood cells, becomes activated when the gene is relocated in the genome. The second type resembles a previously known type of childhood leukaemia, but is caused by other genetic mutations”, says Henrik Lilljebjörn, researcher and project manager of the study.

Previous studies of childhood acute lymphoblastic leukaemia have shown that there are six major groups of acute lymphoblastic leukaemia in children. The discovered two new types, together representing about 10 per cent of all childhood leukaemia, can now be added to these groups.

“Over the last few years, our research group has worked extremely intensely on this study, which would not have been possible without collaboration with several other researchers at Lund University, Skåne University Hospital, and research groups in Germany”, concludes Thoas Fioretos.

The hope is that the findings will lead to improved diagnosis and monitoring of childhood leukaemia, and ultimately new forms of treatment. The research group’s findings are published in the prestigious journal Nature Communications.

The two new types of leukaemia are called “DUX4-rearranged” and “ETV6/RUNX1-like”.

###

The research article is published in Nature Communications “Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in pediatric B-cell precursor acute lymphoblastic leukaemia” Nature Communications on June 06, 2016 2016 http://www.nature.com/ncomms/2016/160606/ncomms11790/full/ncomms11790.html

For more information about the study, please contact:

Thoas Fioretos
Professor of Clinical Genetics at the Division of Clinical Genetics, Lund University,
mobile: 46-0-70-3343367
Email: [email protected]

Henrik Lilljebjörn
research at the Division of Clinical Genetics, Lund University,
Mobile: 46-0-705-613651
Email: [email protected]

Info NGS

Next-generation sequencing (NGS) is a relatively new method that makes it possible to quickly and forcefully determine the genome of an organism. The technology was initially very expensive to use, but in recent years the cost has dropped, making it possible to sequence hundreds of samples at a more reasonable cost.

The research was mainly funded by The Swedish Childhood Cancer Foundation, The Swedish Cancer Society, The Swedish Research Council, the Faculty of Medicine at Lund University and Region Skåne.

Media Contact

Cecilia Schubert
[email protected]
46-073-062-3858
@lunduniversity

http://www.lu.se

The post New types of blood cancer discovered in children appeared first on Scienmag.

Share46Tweet7Share2ShareShareShare1

Related Posts

IMAGE

NUS scientists find new mechanism of cancer formation

January 19, 2021
IMAGE

Novel organoid models: Illuminating path to cervical cancers

January 19, 2021

A master cancer gene hijacks a ‘molecular crowbar’ to make breast cancer cells invasive

January 19, 2021

How to find mutated sperm? Just go FISH

January 19, 2021
Next Post

Origami ninja star inspires new battery design

blank

New mutation-testing technology has potential to guide targeted lung and colorectal cancer therapies

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    The map of nuclear deformation takes the form of a mountain landscape

    54 shares
    Share 22 Tweet 14
  • People living with HIV face premature heart disease and barriers to care

    64 shares
    Share 26 Tweet 16
  • New drug form may help treat osteoporosis, calcium-related disorders

    40 shares
    Share 16 Tweet 10
  • New findings help explain how COVID-19 overpowers the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Infectious/Emerging DiseasesClimate ChangecancerGeneticsCell BiologyTechnology/Engineering/Computer ScienceMaterialsMedicine/HealthEcology/EnvironmentBiologyPublic HealthChemistry/Physics/Materials Sciences

Recent Posts

  • CNIO participates in a study that defines the most important genes that increase breast cancer risk
  • Innovations through hair-thin optical fibres
  • NUI Galway contribute to significant breast cancer risk genes study
  • As oceans warm, large fish struggle
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In