Microbes on explanted pedicle screws: Possible cause of spinal implant failure

CHARLOTTESVILLE, VA (MAY 28, 2019). Pedicle screws are often used to secure surgically implanted hardware to the spine in patients with spinal disease or spinal trauma. In some cases, these screws loosen over time, leading to spinal instability and consequent pain. This is a common complication of spine surgery. One reason suggested for pedicle screw loosening is implant-associated infection, but until now there has been little clinical evidence to support this theory.

In the article “High frequency of low-virulent microorganisms detected by sonication of pedicle screws: a potential cause for implant failure,” published today in the Journal of Neurosurgery: Spine, Vincent Prinz, MD, and colleagues recount their detection of microbial colonization of surgical implant hardware in patients with no apparent clinical signs of infection.

The study focused on 82 patients who underwent surgery during which a spinal hardware implant had to be removed. None of these patients had clinical or laboratory evidence of active infection, and there was no obvious sign of infection during surgery. Following surgery, sonication was used to detect the presence of microbial biofilms on the extracted hardware. This application of sound wave energy breaks apart any sticky biofilm covering surgical implants, separating microorganisms that inhabit it. The microorganisms that had colonized the implants were then examined to specify what types were present.

The authors found evidence of pedicle screw loosening in 54 of the 82 patients; the other 28 patients formed a control group. Sonication verified microbial colonization of extracted hardware with one or more bacteria in 22 (40.7%) of the 54 patients with pedicle screw loosening. Sonication found no microbial colonization in hardware removed from the 28 patients in whom there was no pedicle loosening.

The most commonly found microorganisms were identified as coagulase-negative staphylococci (specifically Staphylococcus epidermis, S. hominis, S. lugdunensis, S. haemolyticus, S. cohnii, and S. saprophyticus). These commensal bacteria are part of the normal flora covering human skin and mucous membranes, where they rarely cause harm to their hosts. The second most commonly found microorganism was Cutibacterium acnes, which, as its name indicates, causes acne and is also commonly found on human skin. All these bacteria carry a low level of virulence. When they aggregate on medical devices implanted within a patient, they form biofilms and can produce infections that show no clinical symptoms and are not easily detected.

The authors examined patient files to find the durations of the initial surgeries in which spinal hardware had first been implanted in the spine. They found a significant difference between the length of surgery in patients in whom microbial colonization of hardware was detected (mean 288 ± 147 minutes) and patients in whom no microbial colonization was found (mean 201 ± 103 minutes).

Based on the relationship between pedicle screw loosening and microbial colonization, the authors suggest that patients in whom infected hardware is replaced would benefit from “systemic biofilm-active antibiotic therapy to prevent new screw loosening.” “Alternatively,” they add, “local antibiotics may be applied, such as the antimicrobial coating of screws or application of local antimicrobial hydrogel or bone substitutes.”

The authors summarize their findings in four take-away points:

• Possible low-virulent implant infection was not revealed by standard preoperative tests.
• There was a significant association between pedicle screw loosening and the presence of low-virulent pathogens on spinal implants.
• Coagulase-negative staphylococci were the most commonly found pathogens colonizing the implants.
• There was a significant association between long surgery times and a higher rate of implant infection.

When asked about the importance of the study, Dr. Vajkoczy said, “The results of our study will add to a paradigm shift in spine surgery, if not more generally, to the common handling of medical hardware implants. Our increasing awareness of slow virulent infections as a cause of late hardware failure has changed our concept of prevention and treating this unfortunate complication of spine surgery. Today, strategies are needed to prevent perioperative implant colonization, disrupt biofilms, and actively search for implant infections by using sonication and advanced microbiological analysis at the time of re-operation. The good news is that infection is a complication that can be treated successfully, if properly diagnosed.”

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Prinz V, Bayerl S, Renz N, Trampuz A, Czabanka M, Woitzik J, Vajkoczy P, Finger T: High frequency of low-virulent microorganisms detected by sonication of pedicle screws: a potential cause for implant failure. J Neurosurg Spine, published ahead of print May 28, 2019. DOI: 10.3171/2019.1.SPINE181025.

Disclosure: This work was supported by an educational grant from the PROIMPLANT Foundation.

Drs. Prinz, Bayerl, Czabanka, Woitzik, Vajkoczy, and Finger are affiliated with the Department of Neurosurgery, and Drs. Renz and Trampuz with the Center for Musculoskeletal Surgery at Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

For additional information, contact: Ms. Jo Ann M. Eliason, Communications Manager, JNS Publishing Group, One Morton Drive, Suite 200, Charlottesville, VA 22903; Email [email protected]; Phone 434-982-1209.

The Journal of Neurosurgery: Spine is a monthly peer-reviewed journal focused on neurosurgical approaches to treatment of diseases and disorders of the spine. It contains a variety of articles, including descriptions of preclinical and clinical research as well as case reports and technical notes. The Journal of Neurosurgery: Spine is one of four monthly journals published by the JNS Publishing Group, the scholarly journal division of the American Association of Neurological Surgeons. Other peer-reviewed journals published by the JNS Publishing Group each month include the Journal of Neurosurgery, Neurosurgical Focus, and the Journal of Neurosurgery: Pediatrics. All four journals can be accessed at http://www.thejns.org.

Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 10,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All active members of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the entire nervous system including the brain, spinal column, spinal cord, and peripheral nerves. For more information, visit http://www.AANS.org.