• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Sunday, January 24, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

May repairs full of mistakes develop into cancer?

Bioengineer by Bioengineer
May 26, 2016
in Cancer
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

It is thought that one of the reasons why cells become cancerous is that the source of genetic information is physically destroyed. Our body has a system to repair DNA damage (DNA repair mechanism), so why a normal cell turns into a cancer cell and why radiation exposure causes cancer have not been clarified.

Radiation damages genomic DNA, the essential blueprint for life; therefore, living organisms have several mechanisms for maintaining the stability of their own genomes. Although they have big evolutionary differences, both humans and budding yeast contain proteins that perform the same function. Miki Shinohara, associate professor and her group at the Institute for Protein Research, Osaka University examined the DNA repair function of yeast Xrs2, an orthlog of human Nbs1, and yeast Tel1, an orthlog of human ATM.

Mutations in the Nbs1 gene are responsible for a human hereditary disorder which develops a high risk of cancer. This group found that DNA damage was repaired when human hereditary disorder type mutations (xrs2 mutations) were introduced in yeast XRS2 genes, but it was repaired with more errors than a DNA sequence with no mutations. This group determined that the cause was that the function of the Tel1 protein, which is important for DNA damage response, was not fully implemented in xrs2 mutations.

In the process of DNA repair through homologous recombination, it is necessary to make double-stranded DNA near DNA lesions into single-stranded DNA. This group clarified that Ku remained on DNA damage in tel1 mutants and xrs2 mutants. Ku is not required, so it should be removed when DNA damage is repaired.

Ku is a protein to join DNA ends broken by non-homologous end joining (NHEJ). It is thought that Ku, a repair tool, joins DNA ends where Ku normally should not work, and as a result, repair is completed with incorrect DNA information.

Tumor formation occurs when genomic DNA is broken or errors have become continuous. In human cells as well, if Nbs1 and ATM function in the same way to ensure repair of DNA damage, tumor formation may be prevented.

This group’s achievement shows the possibility to clarify the mechanism of human tumor formation, especially the molecular mechanism responsible for in the initial stage of cell cancerization due to DNA damaged by radiation in the initial stage, by using the model of budding yeast, a primitive eukaryote. Furthermore, it may be possible to clarify the molecular mechanism of cancerization by radiation exposure by verifying it using human cells.

###

This research was featured in the electronic version of PLOS Genetics on Saturday, March 19, 2016.

Media Contact

Saori Obayashi
[email protected]
81-661-055-886
@osaka_univ_e

http://www.osaka-u.ac.jp/en

The post May repairs full of mistakes develop into cancer? appeared first on Scienmag.

Share26Tweet8Share2ShareShareShare2

Related Posts

IMAGE

University of Cincinnati research unveils possible new combo therapy for head and neck cancer

January 22, 2021
IMAGE

CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)

January 22, 2021

New combination of immunotherapies shows great promise for treating lung cancer

January 22, 2021

Catching cancer in the act

January 21, 2021
Next Post
blank

DARPA $6.4 million contract supports research to enhance resilience after malaria infection

blank

Making injectable medicine safer

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    The map of nuclear deformation takes the form of a mountain landscape

    54 shares
    Share 22 Tweet 14
  • People living with HIV face premature heart disease and barriers to care

    65 shares
    Share 26 Tweet 16
  • New drug form may help treat osteoporosis, calcium-related disorders

    40 shares
    Share 16 Tweet 10
  • New findings help explain how COVID-19 overpowers the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Technology/Engineering/Computer ScienceBiologyClimate ChangePublic HealthMaterialsInfectious/Emerging DiseasesMedicine/HealthcancerGeneticsCell BiologyEcology/EnvironmentChemistry/Physics/Materials Sciences

Recent Posts

  • Regulating the ribosomal RNA production line
  • A professor from RUDN University developed new liquid crystals
  • New technique builds super-hard metals from nanoparticles
  • No more needles for diagnostic tests?
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In