Cancer
Rare Thyroid Lymphoma Returns Six Years Later — and a New Drug Regimen Beats It Back
A new case report in the Annals of Hematology describes a woman whose rare primary thyroid diffuse large B-cell lymphoma...
Hidden Genetic Fault Lines Reshape Gastric Cancer Treatment Maps in Landmark Chinese Cohort
A 563-patient genomic study from Peking University reveals how KMT2C/D loss-of-function alterations define a hypermutated, MSI-high subgroup of gastric cancer...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and...
Hidden Immune Saboteurs: Scientists Map the Cells That Shield Colorectal Tumors
By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings...
Fewer Than One in Ten Lynch Syndrome Patients Use Aspirin to Prevent Colorectal Cancer
A German survey of 539 people with Lynch syndrome found that despite strong evidence that daily aspirin reduces colorectal cancer...
Exercise Gap: Most Men With Advanced Prostate Cancer Walk Enough, but Few Lift Weights
A large international registry study finds that while 58 to 63 percent of men with advanced prostate cancer meet aerobic...
Insulin Receptor Signaling Is Not One Pathway: Engineered Mimetics Reveal a Programmable Network
A new review argues that insulin receptor signaling is a programmable, context-dependent network that engineered mimetics can selectively retune across...
Anemia Strikes Two-Thirds of Late-Stage Cancer Patients, Yet Most Go Untreated
A multicenter study of 1,546 advanced cancer patients in Beijing found that 65.1 percent developed anemia during third-line or later...
Immune Receptor LAIR1 Blocks Cancer Cell Engulfment in Brain Tumours
New research in the British Journal of Cancer shows that the collagen-binding receptor LAIR1 disables the phagocytic machinery of glioma-associated...
Iron and Copper Cell Death Pathways May Hold Key to Beating Immunotherapy Resistance
A new review in Medical Oncology argues that simultaneously inducing the iron-driven cell death ferroptosis and the copper-driven cuproptosis, tuned...
Cancer’s Hidden Proteome: Thousands of Dark Proteins Emerge as Drug Targets
A landmark Perspective in Nature Reviews Cancer argues that the cancer dark proteome — thousands of uncharacterized proteins from non-canonical...
LSU Health New Orleans Hires Star Radiation Oncologist to Build First Academic Department
LSU Health New Orleans has recruited radiation oncologist Dr. Puneeth Iyengar from Memorial Sloan Kettering to establish its first academic...
Cancer Survivors Left in the Dark About Debilitating Bowel Problems After Radiotherapy
A qualitative study of 28 cancer survivors and 19 health professionals finds that information about chronic bowel symptoms after pelvic...
Metadherin emerges as an invasion switch in oral squamous cell carcinoma
New research shows that metadherin, enriched at the invasive front of oral squamous cell carcinoma, drives tumor invasion by selectively...
Faulty Epigenetic Switch Disrupts Brain Cell Cycles and Drives White Matter Defects in Autism-Linked Disorders
New research shows that pathogenic variants in the chromatin regulator MSL2 disrupt oligodendrocyte precursor cell division and myelination through loss...
Rare Partial Triradiate Cartilage Injury Seen in Teen Athlete After Minor Trauma
French clinicians report the first known case of a partial triradiate cartilage injury in a 14-year-old athlete after low-energy trauma,...
Platelets Caught Sabotaging Cancer-Killing Immune Cells Through a Single Molecular Handshake
New research shows that activated platelets bind CD8-positive T cells via P-selectin and PSGL-1, directly suppressing their tumor-killing activity and...
Breast Cancer Cells Recruit Immune Allies Through TNFAIP3 to Drive Metastasis
A new study shows that high TNFAIP3 expression in breast cancer cells drives CCL2/CCR2-mediated M2-like macrophage polarization and that combining...
Estrogen receptor fuels breast cancer growth through an RNA-tagging loop, study finds
New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the...
Hidden Aggression: Machine Learning Exposes Dangerous Biology in Low-Risk Prostate Cancer
Researchers at KTH Royal Institute of Technology used multi-omics analysis and machine learning to uncover molecular features linked to aggressive...
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