Cancer

Proteomic profiling of GOT1 neuroendocrine tumors after lutetium-177 DOTATATE therapy reveals suppressed invasion pathways and altered p53 and stress signaling...

MIT engineers have created a handheld microfluidic device that gently collects living cells from targeted tissue locations, potentially enabling earlier...

A comprehensive Molecular Cancer review explains how antibody-drug conjugates deliver lethal payloads to tumors, why resistance emerges, and which next-generation...

An autopsy-confirmed case reveals shared STAT3 and TET2 mutations linking Felty syndrome to terminal aggressive clonal T-cell disease.

Scientists have grown the first organoids of the visceral pleura, the thin membrane that envelops the lungs, and shown that...

A retrospective landmark and propensity score–matched analysis found that delaying bone-modifying agent therapy beyond six months after a bone metastasis...

A retrospective study of 159 Ugandan children with acute myeloid leukaemia found high rates of induction failure and early death,...

A new study reports that exosomes released by inflamed synovial stem cells carry the circular RNA circRNF20, which worsens rheumatoid...

A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical...

An updated systematic review of seven randomised trials finds that exercise rehabilitation after haematopoietic stem cell transplantation is safe and...

A phase 1 trial found that the investigational BCMA-targeted CAR-T therapy anito-cel produced responses in all 38 participants with relapsed...

A small exploratory study links distinct immature and inflammatory states of circulating high-density neutrophils to both resistance to immune checkpoint...

A Barcelona case series and systematic review of 103 patients map the clinical features, treatment patterns, and high mortality of...

A prospective real-world cohort study finds that proteasome inhibitor-based therapy is not associated with measurable differences in quality of life,...

New research shows that the nuclear envelope protein SUN2 regulates endothelial microtubule dynamics, focal adhesions, and extracellular matrix quality to...

A comprehensive epigenetic analysis led by St. Jude and KiTZ identified the chromatin regulator KDM2B as an essential, selective dependency...

A qualitative study of eleven North Korean defector women with cervical cancer reveals six themes spanning neglect, treatment powerlessness, body...

A meta-analysis of thirty studies finds that elevated preoperative CEA is strongly associated with occult lymph node metastasis in clinical...

A new study reports the first evidence that a B-cell receptor from primary central nervous system lymphoma can react against...

A pan-cancer analysis of 287,745 UK Biobank participants links strong adherence to a healthy lifestyle with lower risks of 13...