Cancer

A retrospective study of 109 patients finds that CD19-directed CAR T-cell therapy reduces nodal and extranodal lymphoma tumors to a...

A qualitative study of 22 Canadians receiving ongoing treatment for advanced cancer identified persistent symptoms, uncertainty, everyday disruption and difficulties...

A retrospective study of 102 adults with grade 4 gliomas in the Democratic Republic of the Congo linked gross total...

The phase III TAISHAN-302 trial found that the anti-B7-H3 antibody-drug conjugate Tam-Peli reduced the risk of death by 54 percent...

A systematic review and meta-analysis of eight studies found elevated serum TK1 in prostate cancer and an association with higher...

Relapsed small-cell lung cancer has long been one of the most difficult malignancies to treat once platinum-based chemotherapy fails, with...

A computational and laboratory study found that reducing HLTF diminished prostate cancer cell proliferation and suggested regulation of ZBP1-PANoptosome assembly...

A prespecified interim analysis of the phase 3 HARMONi-2 trial shows ivonescimab achieved median overall survival of 30.8 months versus...

A retrospective cohort of 163 patients treated at one Rwandan cancer center reported estimated median overall survival of 3.68 years...

In the phase 3 REZILIENT 3 trial, adding zipalertinib to platinum-pemetrexed chemotherapy extended median progression-free survival from 8.5 to 14.5...

A retrospective study of 430 surgically treated patients links elevated inflammation, thyroid-related blood markers and selected immune-cell measures with survival...

A new study shows that VEGF-driven retinal neovascularization depends on a VEGFR2-VEGFR3-ATF6-GRP78 signaling axis that induces the chemokines CXCL1/2 and...

A retrospective study of 47 patients found that high folate receptor alpha expression was independently associated with shorter progression-free survival...

New results from the global Phase I/II ARROS-1 trial indicate clinically meaningful activity with the investigational drug zidesamtinib in patients...

The 50-patient COMPORT phase II trial will prospectively evaluate whether pathology-based omission of low-risk anatomical compartments can individualize postoperative radiotherapy...

University of Pittsburgh researchers created a diet-based mouse model showing that fragile regulatory T cells, shaped by a Western-style diet...

A claims-data study of continuously insured North Carolina adults found that small areas farther from endoscopy facilities had lower prevalence...

The STTARRS protocol plans a nine-hospital Australian randomised trial of telehealth prehabilitation in 480 adults awaiting major cancer surgery, with...

University of Michigan researchers report that the molecular glue RPT04402 stabilizes the trimeric tumor suppressor PP2A, shrinking KRAS-mutant lung tumors...

A single-center cohort study linked checkpoint inhibitor-containing therapy with longer unadjusted progression-free survival in advanced SMARCA4-deficient thoracic tumors, but adjusted...