• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Thursday, August 21, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Breast cancer drug impairs brain function

Bioengineer by Bioengineer
December 24, 2018
in Health
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Findings emphasize need for further investigation of breast cancer treatments and their effects on the brain

IMAGE

Credit: Gervais et al., JNeurosci (2018)


A comprehensive study of monkeys given the breast cancer drug letrozole reveals side effects that impact the brain. Published in JNeurosci, the research establishes the common marmoset as an important nonhuman primate model for studying the effects of estrogen-reducing treatments on the nervous system.

Letrozole is used to prevent breast cancer recurrence by interfering with the production of estrogens. Although side effects such as mood disturbances and memory issues have been reported in both humans and animals, little is known about how the drug impacts the brain.

Nicole Gervais and colleagues administered Letrozole to male and female marmosets via pudding for four weeks and observed many of the same behavioral changes, including hot flashes and increased anxiety, experienced by women receiving similar treatment. Letrozole also compromised the function of neurons in the hippocampus and impaired spatial memory. Together these findings emphasize the need for further investigation of breast cancer treatments and their effects on the brain.

###

Article: Adverse effects of aromatase inhibition on the brain and behavior in a nonhuman primate

DOI: http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0353-18.2018

Corresponding author: Nicole Gervais (University of Toronto, Canada) [email protected]

About JNeurosci

JNeurosci, the Society for Neuroscience’s first journal, was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors’ changing publishing needs, representing breadth of the field and diversity in authorship.

About The Society for Neuroscience

The Society for Neuroscience is the world’s largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and over 130 chapters worldwide.

Media Contact
David Barnstone
[email protected]
202-962-4000

Related Journal Article

http://dx.doi.org/10.1523/JNEUROSCI.0353-18.2018

Tags: Breast CancerMedicine/Health
Share12Tweet8Share2ShareShareShare2

Related Posts

Iran’s Parkinson’s Disease Registry: Key Findings Revealed

Iran’s Parkinson’s Disease Registry: Key Findings Revealed

August 21, 2025
blank

Amputation Doesn’t Alter the Brain’s Body Map: Memories of the Lost Persist

August 21, 2025

New Bacterial Protein Drives Nitrous Oxide Reduction

August 21, 2025

Stable Cortical Body Maps Persist After Arm Amputation

August 21, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Molecules in Focus: Capturing the Timeless Dance of Particles

    141 shares
    Share 56 Tweet 35
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    81 shares
    Share 32 Tweet 20
  • Modified DASH Diet Reduces Blood Sugar Levels in Adults with Type 2 Diabetes, Clinical Trial Finds

    60 shares
    Share 24 Tweet 15
  • Predicting Colorectal Cancer Using Lifestyle Factors

    47 shares
    Share 19 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Circulating miRNAs: Liquid Biomarkers for Pediatric Gliomas

Iran’s Parkinson’s Disease Registry: Key Findings Revealed

SLAS Technology Introduces AI-Enhanced Diagnostics and Advanced Laboratory Innovations

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.