City of Hope scientists are trying to change how doctors treat patients with solid tumors
DUARTE, Calif. — A special blood test may one day predict if a newly diagnosed breast cancer patient will likely relapse years later, a City of Hope study suggests.
“This is the first success linking a solid tumor with blood biomarkers – an indicator of whether a patient will remain in remission,” said Peter P. Lee, M.D., chair of the Department of Immuno-Oncology at City of Hope and corresponding author of the study. “When patients are first diagnosed with cancer, it is important to identify those at higher risk for relapse for more aggressive treatments and monitoring. Staging and new tests based on genomics analysis of the tumor are currently available for risk stratification. However, a predictive blood test would be even more attractive but is not yet available. We are trying to change the status quo.”
The effectiveness of a person’s anti-tumor immune response is determined by the balance between pro-inflammatory and anti-inflammatory signaling pathways in response to cytokines, according to the July 8 Nature Immunology study. Lee and his colleagues used data on 40 breast cancer patients who were followed for a median of four years. Results were validated in a separate cohort of 38 additional breast cancer patients to create a benchmark that predicts if a breast cancer patient will likely relapse within a handful of years.
The balance of cytokine signaling responses in “peripheral blood immune cells” – the engine behind a healthy immune system – are indicators of the overall state of a person’s immune system, said Lee, the Billy and Audrey L. Wilder Professor in Cancer Immunotherapeutics at City of Hope.
“So, these findings may go beyond cancer to address other diseases the immune system must battle,” he added. “This general approach may also be useful for predicting outcomes in patients with autoimmune and infectious diseases.”
A cancer patient’s peripheral blood immune cells, a critical part of the immune system, tends to have decreased pro-inflammatory cytokine signaling responses and increased immune suppressive cytokine signaling responses, meaning a systemic immune environment is created that is conducive to the spread of cancer.
Lee and his colleagues analyzed signaling responses to many pro- and anti-inflammatory cytokines in different immune cell types that are found in peripheral blood from breast cancer patients who were newly diagnosed with the disease. They found altered signaling to four different cytokines (two pro- and two anti-inflammatory) in regulatory T cells in some patients. These cytokine signaling patterns in peripheral blood at diagnosis reflects the state of the immune system and predicts future relapse three to five years later.
The scientists used their data to create a cytokine signaling index (CSI), a sort of benchmark. The idea is that a patient could go in for a blood test and have their data run through an algorithm that will output a number which informs doctors what the patient’s risk of cancer recurrence is within three to five years.
“Knowing the chance of cancer relapse will inform doctors how aggressive a particular patient’s cancer treatment should be,” Lee said. “The CSI is an overall reflection of a patient’s immune system at diagnosis, which we now know is a major determinant of future relapse.”
Scientists from UCLA also contributed to the study, which was supported by the U.S. Department of Defense Breast Cancer Research Program, Stand Up to Cancer, Breast Cancer Research Foundation and the V Foundation.
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About City of Hope
City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases. Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin and numerous breakthrough cancer drugs are based on technology developed at the institution. A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked one of America’s “Best Hospitals” in cancer by U.S. News & World Report
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