Findings could lead to treatment that reduces health risks from exposure to hexavalent chromium
Orlando, Fla. (April 8, 2019) – Antioxidants such as vitamin C could help reduce harmful effects from hexavalent chromium, according to a new study performed with human cells. The contaminant, which is often produced by industrial processes, was featured in the biographical movie Erin Brockovich.
Federal data from nationwide drinking water tests show that the compound contaminates water supplies for more than 200 million Americans in all 50 states. The concentration of hexavalent chromium that is safe for drinking water is now under review by the U.S. Environmental Protection Agency.
“This is the first study to use human cells to test the effects of hexavalent chromium and protection by antioxidants,” said Tim Mayotte, an undergraduate student at Olivet Nazarene University who performed the study. “If the new findings are further validated and go on to clinical trials, it might be possible to treat at-risk water sources with antioxidants like vitamin C to lower the risk for cancer caused by hexavalent chromium.”
Mayotte will present this research at the American Society for Biochemistry and Molecular Biology annual meeting during the 2019 Experimental Biology meeting to be held April 6-9 in Orlando, Fla.
In a study designed to find out whether antioxidants might prevent cell toxicity, the researchers exposed two types of human cells to various concentrations of hexavalent chromium. They observed toxic effects for both cell types at 200 parts per billion (ppb) or higher concentrations of hexavalent chromium. However, this toxicity could be blocked by vitamin C at 10 parts per million (ppm) or the antioxidant epigallocatechin gallate at 15 (ppm). Epigallocatechin gallate is the primary antioxidant found in green tea.
In other experiments, the researchers saw DNA mutations in bacteria exposed to 20 ppb or more of hexavalent chromium. However, these mutations didn’t occur when the bacteria were also treated with 20 ppm of vitamin C.
The new findings reveal that an oxidative mechanism is likely responsible for the contaminant’s toxicity, which could be prevented by treating the water with antioxidants. These results could help inform water quality monitoring and regulation.
Tim Mayotte will present the findings from 11:45 a.m. -1:00 p.m. Monday, April 8, in Exhibit Hall-West Hall B, Orange County Convention Center (poster E238 634.9) (abstract). Contact the media team for more information or to obtain a free press pass to attend the meeting.
About Experimental Biology 2019
Experimental Biology is an annual meeting comprised of more than 14,000 scientists and exhibitors from five host societies and multiple guest societies. With a mission to share the newest scientific concepts and research findings shaping clinical advances, the meeting offers an unparalleled opportunity for exchange among scientists from across the United States and the world who represent dozens of scientific areas, from laboratory to translational to clinical research.
About the American Society for Biochemistry and Molecular Biology (ASBMB)
ASBMB is a nonprofit scientific and educational organization with more than 12,000 members worldwide. Founded in 1906 to advance the science of biochemistry and molecular biology, the society publishes three peer-reviewed journals, advocates for funding of basic research and education, supports science education at all levels, and promotes the diversity of individuals entering the scientific workforce. http://www.
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Anne Frances Johnson