• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Sunday, August 3, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home Headlines

Starvation causes atypical cell death

Bioengineer.org by Bioengineer.org
January 19, 2018
in Headlines, Health, Science News
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: IDIBELL

Researchers from the Cell death group of the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Cristina Muñoz-Pinedo, have characterized the cell death process due to starvation, in which the endoplasmic reticulum plays a leading role. Their work, chosen as the cover of the latest Molecular and Cellular Biology journal, was carried out within TRAIN-ERs, a European collaborative action that studies diseases associated with this cellular organelle.

"Usually, programmed cell death — also called apoptosis — follows a biochemical pathway related to the permeabilization of mitochondria; However, we observed that in cases of cell death due to lack of glucose, cells die in an unexpected way, following a process similar to what we would expect from an immune response", explains Dr. Cristina Muñoz-Pinedo, last author of the study.

In cell-death-related treatments such as chemotherapy, the mitochondrial pathway is activated. Instead, when starved, cells activate the so-called "death receptors" on their membrane, which are normally used by the lymphocytes of the immune system to attack and destroy infected cells.

IDIBELL researchers have been able to relate the activation of these membrane receptors to the endoplasmic reticulum, a cellular organelle involved in protein synthesis and lipid metabolism, as well as intracellular transport. "Feeling the stress produced by the lack of nutrients, the reticulum send an alarm signal that triggers the appearance of death receptors in the membrane", says Dr. Muñoz-Pinedo.

"According to our in vitro results, we assume that this is how the tumor cells located in the center of a tumor — the so-called necrotic core — die, because there are never enough nutrients in those areas", adds the IDIBELL researcher. "On the other hand, in ischemia, besides the lack of oxygen there is also cell death due to lack of glucose, so this process could also be related to the activity of the endoplasmic reticulum at a biochemical level".

###

This work was possible thanks to the funding received from the European Marie Curie TRAIN-ERs network, which supports and trains young researchers to develop strategies for the treatment of diseases associated with endoplasmic reticulum stress. "Within TRAIN-ERs, the goal of our research group was to study the role of endoplasmic reticulum stress signals in starvation, and we have shown that it is essential," says Muñoz-Pinedo.

Endoplasmic reticulum (ER) stress is emerging recently as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases, affecting millions of patients annually worldwide and assuming a huge economic burden for the health sector.

Media Contact

Gemma Fornons
[email protected]
0034-638-685-074
@idibell_en

Inicio

Original Source

http://www.idibell.cat/modul/news/en/996/starvation-causes-atypical-cell-death http://dx.doi.org/10.1128/MCB.00479-16.

Share12Tweet7Share2ShareShareShare1

Related Posts

blank

NSUN5 Drives Liver Cancer via m5C-EFNA3 Glycolysis

August 3, 2025
blank

Noradrenaline Boosts Amygdala Memory Precision for Similar Events

August 3, 2025

Rigid Crosslinker Enables Nondestructive Patterned QLEDs

August 3, 2025

Predicting Hidden Cervical Cancer via Cytology, ECC

August 3, 2025
Please login to join discussion

POPULAR NEWS

  • Blind to the Burn

    Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    60 shares
    Share 24 Tweet 15
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    48 shares
    Share 19 Tweet 12
  • Dr. Miriam Merad Honored with French Knighthood for Groundbreaking Contributions to Science and Medicine

    46 shares
    Share 18 Tweet 12
  • Study Reveals Beta-HPV Directly Causes Skin Cancer in Immunocompromised Individuals

    38 shares
    Share 15 Tweet 10

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

NSUN5 Drives Liver Cancer via m5C-EFNA3 Glycolysis

Noradrenaline Boosts Amygdala Memory Precision for Similar Events

Rigid Crosslinker Enables Nondestructive Patterned QLEDs

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.