{"id":700,"date":"2013-06-06T17:32:21","date_gmt":"2013-06-06T17:32:21","guid":{"rendered":"http:\/\/bioengineer.org\/?p=700"},"modified":"2013-09-18T08:12:50","modified_gmt":"2013-09-18T08:12:50","slug":"scientists-discover-how-hiv-kills-immune-cells","status":"publish","type":"post","link":"https:\/\/bioengineer.org\/scientists-discover-how-hiv-kills-immune-cells\/","title":{"rendered":"Scientists Discover How HIV Kills Immune Cells"},"content":{"rendered":"

HIV replicates inside infection-fighting human immune cells called CD4+ T cells through complex processes that include inserting its genes into cellular DNA. The scientists discovered that during this integration step, a cellular enzyme called DNA-dependent protein kinase (DNA-PK) becomes activated. DNA-PK normally coordinates the repair of simultaneous breaks in both strands of molecules that comprise DNA. As HIV integrates its genes into cellular DNA, single-stranded breaks occur where viral and cellular DNA meet. Nevertheless, the scientists discovered, the DNA breaks during HIV integration surprisingly activate DNA-PK, which then performs an unusually destructive role: eliciting a signal that causes the CD4+ T cell to die. The cells that succumb to this death signal are the very ones mobilized to fight the infection.<\/p>\n

According to the scientists, these new findings suggest that treating HIV-infected individuals with drugs that block early steps of viral replication \u2014 up to and including activation of DNA-PK and integration \u2014 not only can prevent viral replication, but also may improve CD4+ T cell survival and immune function. The findings also may shed light on how reservoirs of resting HIV-infected cells develop and may aid efforts to eliminate these sites of persistent infection.<\/p>\n

Story Source:
\nThe above story is reprinted from materials provided by NIH\/National Institute of Allergy and Infectious Diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"

HIV replicates inside infection-fighting human immune cells called CD4+ T cells through complex processes that include inserting its genes into cellular DNA. The scientists discovered that during this integration step, a cellular enzyme called DNA-dependent protein kinase (DNA-PK) becomes activated. DNA-PK normally coordinates the repair of simultaneous breaks in both strands of molecules that comprise […]<\/p>\n","protected":false},"author":8,"featured_media":701,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[176,192],"tags":[],"class_list":["post-700","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioengineering-news","category-headlines"],"_links":{"self":[{"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/posts\/700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/comments?post=700"}],"version-history":[{"count":0,"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/posts\/700\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/media\/701"}],"wp:attachment":[{"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/media?parent=700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/categories?post=700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bioengineer.org\/wp-json\/wp\/v2\/tags?post=700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} BIOENGINEER.ORG

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